Alteration of gut microbiota in inflammatory bowel disease (IBD): cause or consequence? IBD treatment targeting the gut microbiome

I Khan, N Ullah, L Zha, Y Bai, A Khan, T Zhao, T Che… - Pathogens, 2019 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic complex inflammatory gut pathological
condition, examples of which include Crohn's disease (CD) and ulcerative colitis (UC) …

Pathomechanisms of oxidative stress in inflammatory bowel disease and potential antioxidant therapies

T Tian, Z Wang, J Zhang - Oxidative medicine and cellular …, 2017 - Wiley Online Library
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease whose incidence has
risen worldwide in recent years. Accumulating evidence shows that oxidative stress plays an …

Innate and adaptive immunity in inflammatory bowel disease

A Geremia, P Biancheri, P Allan, GR Corazza… - Autoimmunity …, 2014 - Elsevier
Inflammatory bowel disease (IBD) includes Crohn's disease (CD) and ulcerative colitis (UC).
The exact cause of IBD remains unknown. Available evidence suggests that an abnormal …

Targeting IL-17 and TH17 cells in chronic inflammation

P Miossec, JK Kolls - Nature reviews Drug discovery, 2012 - nature.com
The key role of interleukin-17 (IL-17) and T helper 17 (TH17) cells in tissue inflammation,
autoimmunity and host defence led to the experimental targeting of these molecules in …

[HTML][HTML] A cellular and molecular view of T helper 17 cell plasticity in autoimmunity

R Stadhouders, E Lubberts, RW Hendriks - Journal of autoimmunity, 2018 - Elsevier
Since the original identification of the T helper 17 (Th17) subset in 2005, it has become
evident that these cells do not only contribute to host defence against pathogens, such as …

Effector T helper cell subsets in inflammatory bowel diseases

T Imam, S Park, MH Kaplan, MR Olson - Frontiers in immunology, 2018 - frontiersin.org
The gastrointestinal tract is a site of high immune challenge, as it must maintain a delicate
balance between tolerating luminal contents and generating an immune response toward …

Intestinal mucosal barrier function in health and disease

JR Turner - Nature reviews immunology, 2009 - nature.com
Mucosal surfaces are lined by epithelial cells. These cells establish a barrier between
sometimes hostile external environments and the internal milieu. However, mucosae are …

Data quality control in genetic case-control association studies

CA Anderson, FH Pettersson, GM Clarke, LR Cardon… - Nature protocols, 2010 - nature.com
This protocol details the steps for data quality assessment and control that are typically
carried out during case-control association studies. The steps described involve the …

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

J Chen, EE Bardes, BJ Aronow… - Nucleic acids …, 2009 - academic.oup.com
Abstract ToppGene Suite (http://toppgene. cchmc. org; this web site is free and open to all
users and does not require a login to access) is a one-stop portal for (i) gene list functional …

[PDF][PDF] The intestinal barrier function and its involvement in digestive disease

E Salvo Romero, C Alonso Cotoner… - Rev Esp Enferm …, 2015 - online.reed.es
The gastrointestinal mucosal surface is lined with epithelial cells representing an effective
barrier made up with intercellular junctions that separate the inner and the outer …