Ubiquitination is a multi-step enzymatic process that involves the marking of a substrate
protein by bonding a ubiquitin and protein for proteolytic degradation mainly via the ubiquitin …

E3 ubiquitin ligases determine the substrate specificity and catalyze the ubiquitination of
lysine residues. HUWE1 is a catalytic HECT domain-containing giant E3 ligase that contains …

Glioblastoma is the most common primary brain tumor in adults with poor overall outcome
and 5-year survival of less than 5%. Treatment has not changed much in the last decade or …

Ubiquitination plays an essential role in signal transduction to regulate most if not all cellular
processes. Among the enzymes that are involved in the ubiquitin (Ub) signaling cascade …

Sequence variants and duplications in the HECT, UBA and WWE domain–containing 1
(HUWE1) E3 ubiquitin ligase gene have been associated with X-linked mild to severe …

Background: Immune thrombocytopenic purpura (ITP) is an autoimmune bleeding disorder
and the decreased number and immunosuppressive dysfunction of Treg cells are key …

The identification of driver pathways has attracted considerable attention in recent years due
to the high significance of driver pathways in cancer related studies. In most identification …

There are 28 unique human members of the homologous to E6AP C-terminus (HECT) E3
ubiquitin ligase family. Each member of the HECT E3 ubiquitin ligases contains a conserved …

WNT/β-catenin signaling is mediated by the transcriptional coactivator β-catenin (CTNNB1).
CTNNB1 abundance is regulated by phosphorylation and proteasomal degradation …

Phosphorylation-dependent binding of the S. cerevisiae Spt6p tSH2 domain (Spt6ptSH2) to
the Rbp1p subunit of RNA polymerase II supports efficient transcription. Here, we report that …