Mechanisms of gene silencing by double-stranded RNA
Double-stranded RNA (dsRNA) is an important regulator of gene expression in many
eukaryotes. It triggers different types of gene silencing that are collectively referred to as …
eukaryotes. It triggers different types of gene silencing that are collectively referred to as …
RNA interference: biology, mechanism, and applications
N Agrawal, PVN Dasaradhi, A Mohmmed… - Microbiology and …, 2003 - Am Soc Microbiol
Double-stranded RNA-mediated interference (RNAi) is a simple and rapid method of
silencing gene expression in a range of organisms. The silencing of a gene is a …
silencing gene expression in a range of organisms. The silencing of a gene is a …
A gene-coexpression network for global discovery of conserved genetic modules
To elucidate gene function on a global scale, we identified pairs of genes that are
coexpressed over 3182 DNA microarrays from humans, flies, worms, and yeast. We found …
coexpressed over 3182 DNA microarrays from humans, flies, worms, and yeast. We found …
Genome-wide RNAi screening in Caenorhabditis elegans
RS Kamath, J Ahringer - Methods, 2003 - Elsevier
In Caenorhabditis elegans, introduction of double-stranded RNA (dsRNA) results in the
specific inactivation of an endogenous gene with corresponding sequence; this technique is …
specific inactivation of an endogenous gene with corresponding sequence; this technique is …
Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation
MicroRNAs (miRNAs) are∼ 22 nucleotide RNAs that negatively regulate the expression of
protein-coding genes. In a present model of miRNA function in animals, miRNAs that form …
protein-coding genes. In a present model of miRNA function in animals, miRNAs that form …
Revealing the world of RNA interference.
CC Mello, D Conte Jr - Nature, 2004 - nature.com
The recent discoveries of RNA interference and related RNA silencing pathways have
revolutionized our understanding of gene regulation. RNA interference has been used as a …
revolutionized our understanding of gene regulation. RNA interference has been used as a …
Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology
The nematode Caenorhabditis elegans has emerged as an important animal model in
various fields including neurobiology, developmental biology, and genetics. Characteristics …
various fields including neurobiology, developmental biology, and genetics. Characteristics …
[HTML][HTML] Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
Summary Insulin/IGF-1-like signaling (IIS) is central to growth and metabolism and has a
conserved role in aging. In C. elegans, reductions in IIS increase stress resistance and …
conserved role in aging. In C. elegans, reductions in IIS increase stress resistance and …
SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis
A Peragine, M Yoshikawa, G Wu… - Genes & …, 2004 - genesdev.cshlp.org
Higher plants undergo a transition from a juvenile to an adult phase of vegetative
development prior to flowering. Screens for mutants that undergo this transition precociously …
development prior to flowering. Screens for mutants that undergo this transition precociously …
Guidelines on nicotine dose selection for in vivo research
Rationale This review provides insight for the judicious selection of nicotine dose ranges
and routes of administration for in vivo studies. The literature is replete with reports in which …
and routes of administration for in vivo studies. The literature is replete with reports in which …