Background Non-alcoholic fatty liver disease, or as recently proposed 'metabolic-associated
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Aims Loss-of-function mutations in ANGPTL3 are associated with beneficial effects on lipid
and glucose metabolism and reduced risk of coronary artery disease. Vupanorsen (AKCEA …

Background Loss-of-function variants in the angiopoietin-like 3 gene (ANGPTL3) have been
associated with decreased plasma levels of triglycerides, low-density lipoprotein (LDL) …

Background The liver is a key regulator of systemic energy homeostasis and can sense and
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …

Angiopoietin-like protein (ANGPTL) 3 regulates plasma lipids by inhibiting LPL and
endothelial lipase (EL). ANGPTL3 inactivation lowers LDL-C independently of the classical …

Lowering the levels of LDL cholesterol in the plasma has been shown to reduce the risk of
atherosclerotic cardiovascular disease (ASCVD). Several other lipoproteins, such as …

Lipoprotein lipase (LPL) is one of the most important factors in systemic lipid partitioning and
metabolism. It mediates intravascular hydrolysis of triglycerides packed in lipoproteins such …

This review summarizes the latest findings in the literature of Angiopoietin-2 (Ang-2),
Tyrosine-protein kinase receptor (Tie-2) complex, and faricimab along with their involvement …

Abstract In mammals, triglyceride (TG), the main form of lipids for storing and providing
energy, is stored in white adipose tissue (WAT) after food intake, while during fasting it is …