Cholangiocarcinoma
Cholangiocarcinoma (CCA) is a highly lethal adenocarcinoma of the hepatobiliary system,
which can be classified as intrahepatic, perihilar and distal. Each anatomic subtype has …
which can be classified as intrahepatic, perihilar and distal. Each anatomic subtype has …
[HTML][HTML] Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
L Zhong, Y Li, L **ong, W Wang, M Wu… - Signal transduction and …, 2021 - nature.com
Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …
[HTML][HTML] Futibatinib for FGFR2-Rearranged Intrahepatic Cholangiocarcinoma
Background Alterations in fibroblast growth factor receptor 2 (FGFR2) have emerged as
promising drug targets for intrahepatic cholangiocarcinoma, a rare cancer with a poor …
promising drug targets for intrahepatic cholangiocarcinoma, a rare cancer with a poor …
Liver tumour immune microenvironment subtypes and neutrophil heterogeneity
The heterogeneity of the tumour immune microenvironment (TIME), organized by various
immune and stromal cells, is a major contributing factor of tumour metastasis, relapse and …
immune and stromal cells, is a major contributing factor of tumour metastasis, relapse and …
Infigratinib (BGJ398) in previously treated patients with advanced or metastatic cholangiocarcinoma with FGFR2 fusions or rearrangements: mature results from a …
Background Treatment options are sparse for patients with advanced cholangiocarcinoma
after progression on first-line gemcitabine-based therapy. FGFR2 fusions or rearrangements …
after progression on first-line gemcitabine-based therapy. FGFR2 fusions or rearrangements …
[HTML][HTML] Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma
We performed proteogenomic characterization of intrahepatic cholangiocarcinoma (iCCA)
using paired tumor and adjacent liver tissues from 262 patients. Integrated proteogenomic …
using paired tumor and adjacent liver tissues from 262 patients. Integrated proteogenomic …
Cholangiocarcinoma 2020: the next horizon in mechanisms and management
Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant
tumours that can arise at any point of the biliary tree. Their incidence is increasing globally …
tumours that can arise at any point of the biliary tree. Their incidence is increasing globally …
[HTML][HTML] Lipid alterations in chronic liver disease and liver cancer
Lipids are a complex and diverse group of molecules with crucial roles in many
physiological processes, as well as in the onset, progression, and maintenance of cancers …
physiological processes, as well as in the onset, progression, and maintenance of cancers …
Pemigatinib for previously treated, locally advanced or metastatic cholangiocarcinoma: a multicentre, open-label, phase 2 study
Background Fibroblast growth factor receptor (FGFR) 2 gene alterations are involved in the
pathogenesis of cholangiocarcinoma. Pemigatinib is a selective, potent, oral inhibitor of …
pathogenesis of cholangiocarcinoma. Pemigatinib is a selective, potent, oral inhibitor of …
DNA methylation profiling: an emerging paradigm for cancer diagnosis
Histomorphology has been a mainstay of cancer diagnosis in anatomic pathology for many
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …