Advances in quantitative biomarker development have accelerated new forms of data-driven
insights for patients with cancer. However, most approaches are limited to a single mode of …

Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the
tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet …

Background & Aims The liver is a metabolically active organ and is also 'tolerogenic',
exhibiting sophisticated mechanisms of immune regulation that prevent pathogen attacks …

Primary liver cancer is a challenging global health concern with an estimated more than a
million persons to be affected annually by the year 2025. The commonest type is …

Untargeted methods are typically used in the detection and discovery of small organic
compounds in metabolomics research, and ultra-high-performance liquid chromatography …

Gastric cancer (GC) represents a significant burden of cancer-related mortality worldwide,
underscoring an urgent need for the development of early detection strategies and precise …

The employment of liquid chromatography‐mass spectrometry (LC‐MS) untargeted and
targeted metabolomics has led to the discovery of novel biomarkers and improved the …

Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in
cancer remains elusive. Here, using integrative metabolomics and transcriptomics analyses …

Hepatocellular carcinoma (HCC) is one of the most malignant cancer with high morbidity
and mortality which lead to a serious burden to society. AFP (alpha-fetoprotein) is the most …

Metabolomics is the study of the investigation of small molecules derived from cellular and
organism metabolism, which reflects the outcomes of the complex network of biochemical …