Mutations in the GNAO1 gene cause a complex constellation of neurological disorders
including epilepsy, developmental delay, and movement disorders. GNAO1 encodes Gα o …

There are various types of receptors in the central nervous system (CNS). G protein-coupled
receptors (GPCRs) have the highest expression with a wide range of physiological …

Background Autism spectrum disorders (ASD) are associated with dysregulation of the
microbiota-gut-brain axis, changes in microbiota composition as well as in the fecal, serum …

Endometriosis is an estrogen-dependent inflammatory disorder among reproductive-aged
women associated with pelvic pain, anxiety, and depression. Pain is characterized by …

GPR88 is an orphan class A G-protein-coupled receptor that is highly expressed in the
striatum and regulates diverse brain and behavioral functions. Here we present cryo-EM …

This paper is the thirty-ninth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2016 …

G protein coupled receptors (GPCRs) are the main mediators of signal transduction in the
central nervous system. Therefore, it is not surprising that many GPCRs have long been …

The present article provides a historical review of the place and response learning plus-
maze tasks with a focus on the behavioral and neurobiological findings. The article begins …

G-protein-coupled receptors (GPCRs) form the largest receptor family, relay environmental
stimuli to changes in cell behavior and represent prime drug targets. Many GPCRs are …

Traditional antidepressants largely interfere with monoaminergic transport or degradation
systems, taking several weeks to have their therapeutic actions. Moreover, a large …