Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types
of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of …

Over the past several years, studies on normal and malignant B cells have provided new
insights into the unique physiology of the germinal centre (GC). In particular, advances in …

The shortage of organs for transplantation is a major barrier to the treatment of organ failure.
Although porcine organs are considered promising, their use has been checked by …

Large-scale genetic analysis of lethal phenotypes has elucidated the molecular
underpinnings of many biological processes. Using the bacterial clustered regularly …

This presentation represents consensus recommendations for the clinicopathological
definition of Waldenstrom's macroglobulinemia (WM), which were prepared in conjunction …

The transcription factor Pax5 is essential for commitment of lymphoid progenitors to the B
lymphocyte lineage. Pax5 fulfils a dual role by repressing B lineage'inappropriate'genes and …

Reciprocal chromosomal translocations involving the immunoglobulin (Ig) loci are a
hallmark of most mature B cell lymphomas and usually result in dysregulated expression of …

When the regulation of B-cell differentiation and activation is disrupted, lymphomas and
leukaemias can occur. The processes that normally create immunoglobulin diversity might …

A new monoclonal antibody (MUM1p) was used to study the cell/tissue expression of human
MUM1/IRF4 protein, the product of the homologous gene involved in the myeloma …

The B cell lineage of the hematopoietic system is responsible for the generation of high-
affinity antibodies, which provide humoral immunity for protection against foreign pathogens …