Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

While gap junctions support the exchange of a number of molecules between neighboring
cells, connexin hemichannels provide communication between the cytosol and the …

Impaired wound healing is a common and potentially serious complication in patients with
diabetes. In recent years, disturbed physiologic functions of epidermal keratinocytes have …

Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate
direct intercellular communication, a critical feature for the development, function, and …

Scarring and regeneration are two physiologically opposite endpoints to skin injuries, with
mammals, including humans, typically healing wounds with fibrotic scars. We aim to provide …

Diabetes mellitus (DM) is an important cause of chronic wounds and non-traumatic
amputation. The prevalence and number of cases of diabetic mellitus are increasing …

Inflammation may be caused by a variety of factors and is a hallmark of a plethora of acute
and chronic diseases. The purpose of inflammation is to eliminate the initial cell injury …

Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a
leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo …

The most ubiquitous gap junction protein within the body, connexin 43 (Cx43), is a target of
interest for modulating the dermal wound healing response. Observational studies found …

Transdermal delivery of therapeutic biomolecules (including peptides) can avoid enzymatic
digestion that occurs in the oral route.(Polyethylene glycol) diacrylate (PEGDA)‐based …