Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …

Cell death is critical for the development and homeostasis of almost all multicellular
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …

Enhancing the intracellular labile iron pool (LIP) represents a powerful, yet untapped
strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron …

Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …

Although the conventional activities of p53 such as cell cycle arrest, senescence, and
apoptosis are well accepted as the major checkpoints in stress responses, accumulating …

Ferroptosis is an iron-catalysed form of regulated cell death, which is critically dependent on
phospholipid peroxidation of cellular membranes. Ferrostatin 1 was one of the first synthetic …

Ferroptosis is an iron-dependent and lipid peroxidation-driven cell death cascade, occurring
when there is an imbalance of redox homeostasis in the cell. Nuclear factor erythroid 2 …

Although transition metals constitute less than 0.1% of the total mass within a human body,
they have a substantial impact on fundamental biological processes across all kingdoms of …

The research field of ferroptosis has seen exponential growth over the past few years, since
the term was coined in 2012. This unique modality of cell death, driven by iron-dependent …

The discovery of regulated cell death processes has enabled advances in cancer treatment.
In the past decade, ferroptosis, an iron-dependent form of regulated cell death driven by …