Vitamin A update: forms, sources, kinetics, detection, function, deficiency, therapeutic use and toxicity

A Carazo, K Macáková, K Matoušová, LK Krčmová… - Nutrients, 2021 - mdpi.com
Vitamin A is a group of vital micronutrients widely present in the human diet. Animal-based
products are a rich source of the retinyl ester form of the vitamin, while vegetables and fruits …

Retinoic acid receptors: from molecular mechanisms to cancer therapy

A Di Masi, L Leboffe, E De Marinis, F Pagano… - Molecular aspects of …, 2015 - Elsevier
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

De Novo Design of Bioactive Small Molecules by Artificial Intelligence

D Merk, L Friedrich, F Grisoni… - Molecular …, 2018 - Wiley Online Library
Generative artificial intelligence offers a fresh view on molecular design. We present the first‐
time prospective application of a deep learning model for designing new druglike …

Vitamin effects on the immune system: vitamins A and D take centre stage

JR Mora, M Iwata, UH Von Andrian - Nature reviews immunology, 2008 - nature.com
Vitamins are essential constituents of our diet that have long been known to influence the
immune system. Vitamins A and D have received particular attention in recent years as …

[HTML][HTML] β-Carotene is an important vitamin A source for humans

T Grune, G Lietz, A Palou, AC Ross, W Stahl… - The Journal of …, 2010 - Elsevier
Experts in the field of carotenoids met at the Hohenheim consensus conference in July 2009
to elucidate the current status of β-carotene research and to summarize the current …

Vitamin A and retinoid signaling: genomic and nongenomic effects: thematic review series: fat-soluble vitamins: vitamin A

Z Al Tanoury, A Piskunov, C Rochette-Egly - Journal of lipid research, 2013 - ASBMB
Vitamin A or retinol is arguably the most multifunctional vitamin in the human body, as it is
essential from embryogenesis to adulthood. The pleiotropic effects of vitamin A are exerted …

Skeletal anomalies in reared E uropean fish larvae and juveniles. Part 2: main typologies, occurrences and causative factors

C Boglione, E Gisbert, P Gavaia… - Reviews in …, 2013 - Wiley Online Library
The presence of skeletal anomalies in farmed teleost fish is currently a major problem in
aquaculture, entailing economical, biological and ethical issues. The common occurrence of …

Chiral toxicology: it's the same thing… only different

SW Smith - Toxicological sciences, 2009 - academic.oup.com
Chiral substances possess a unique architecture such that, despite sharing identical
molecular formulas, atom-to-atom linkages, and bonding distances, they cannot be …

Retinoid X receptor gamma signaling accelerates CNS remyelination

JK Huang, AA Jarjour, B Nait Oumesmar… - Nature …, 2011 - nature.com
The molecular basis of CNS myelin regeneration (remyelination) is poorly understood. We
generated a comprehensive transcriptional profile of the separate stages of spontaneous …

Multi-target approaches in metabolic syndrome

FF Lillich, JD Imig, E Proschak - Frontiers in pharmacology, 2021 - frontiersin.org
Metabolic syndrome (MetS) is a highly prevalent disease cluster worldwide. It requires
polypharmacological treatment of the single conditions including type II diabetes …