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ATP‐binding cassette (ABC) transporters in cancer: A review of recent updates
The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …
Repositioning lidocaine as an anticancer drug: the role beyond anesthesia
D Zhou, L Wang, Q Cui, R Iftikhar, Y ** multidrug resistance (MDR). Unfortunately …
[HTML][HTML] Venetoclax, a BCL-2 inhibitor, enhances the efficacy of chemotherapeutic agents in wild-type ABCG2-overexpression-mediated MDR cancer cells
Previous studies have shown that small-molecule BCL-2 inhibitors can have a synergistic
interaction with ABCG2 substrates in chemotherapy. Venetoclax is a potent and selective …
interaction with ABCG2 substrates in chemotherapy. Venetoclax is a potent and selective …
[HTML][HTML] Overexpression of ABCB1 transporter confers resistance to mTOR inhibitor WYE-354 in cancer cells
The overexpressing ABCB1 transporter is one of the key factors leading to multidrug
resistance (MDR). Thus, many ABCB1 inhibitors have been found to be able to overcome …
resistance (MDR). Thus, many ABCB1 inhibitors have been found to be able to overcome …
Sitravatinib, a Tyrosine Kinase Inhibitor, Inhibits the Transport Function of ABCG2 and Restores Sensitivity to Chemotherapy-Resistant Cancer Cells in vitro
Sitravatinib, also called MGCD516 or MG-516, is a broad-spectrum tyrosine kinase inhibitor
(TKI) under phase III clinical evaluation. Herein, we explored the activity of sitravatinib …
(TKI) under phase III clinical evaluation. Herein, we explored the activity of sitravatinib …
Dual TTK/CLK2 inhibitor, CC‐671, selectively antagonizes ABCG2‐mediated multidrug resistance in lung cancer cells
One pivotal factor that leads to multidrug resistance (MDR) is the overexpression of ABCG2.
Therefore, tremendous effort has been devoted to the search of effective reversal agents to …
Therefore, tremendous effort has been devoted to the search of effective reversal agents to …
Reversal of cancer multidrug resistance (MDR) mediated by ATP-binding cassette transporter G2 (ABCG2) by AZ-628, a RAF kinase inhibitor
Overexpression of ABCG2 remains a major impediment to successful cancer treatment,
because ABCG2 functions as an efflux pump of chemotherapeutic agents and causes …
because ABCG2 functions as an efflux pump of chemotherapeutic agents and causes …
Modulating the function of ABCB1: in vitro and in vivo characterization of sitravatinib, a tyrosine kinase inhibitor
Background Overexpression of ATP‐binding cassette (ABC) transporter is a major
contributor to multidrug resistance (MDR), in which cancer cells acquire resistance to a wide …
contributor to multidrug resistance (MDR), in which cancer cells acquire resistance to a wide …
Recent research progress of chiral small molecular antitumor-targeted drugs approved by the FDA from 2011 to 2019
X Chu, Y Bu, X Yang - Frontiers in Oncology, 2021 - frontiersin.org
Chiral drugs usually contain chiral centers, which are present as single enantiomers or
racemates. Compared with achiral drugs, they have significant advantages in safety and …
racemates. Compared with achiral drugs, they have significant advantages in safety and …