The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

Y Huang, W Hong, X Wei - Journal of hematology & oncology, 2022 - Springer
Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

Mechanical regulation of chromatin and transcription

S Dupont, SA Wickström - Nature Reviews Genetics, 2022 - nature.com
Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Epithelial-mesenchymal plasticity in cancer progression and metastasis

W Lu, Y Kang - Developmental cell, 2019 - cell.com
Epithelial-to-mesenchymal transition (EMT) and its reversed process, mesenchymal-to-
epithelial transition (MET), are fundamental processes in embryonic development and tissue …

EMT factors and metabolic pathways in cancer

I Georgakopoulos-Soares, DV Chartoumpekis… - Frontiers in …, 2020 - frontiersin.org
The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …

Molecular mechanisms of epithelial–mesenchymal transition

S Lamouille, J Xu, R Derynck - Nature reviews Molecular cell biology, 2014 - nature.com
The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as
epithelial–mesenchymal transition (EMT), is integral in development, wound healing and …

Epithelial–mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities

Z Huang, Z Zhang, C Zhou, L Liu, C Huang - MedComm, 2022 - Wiley Online Library
Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their
junctions and polarity while acquiring mesenchymal properties and invasive ability …

Aberrant regulation and function of microRNAs in cancer

BD Adams, AL Kasinski, FJ Slack - Current Biology, 2014 - cell.com
Malignant neoplasms are consistently among the top four leading causes of death in all age
groups in the United States, despite a concerted effort toward develo** novel therapeutic …

The role of EMT and MET in cancer dissemination

J Banyard, DR Bielenberg - Connective tissue research, 2015 - Taylor & Francis
Metastatic cancer cells are lethal. Understanding the molecular mechanisms that bolster the
conversion from benign to malignant progression is key for treating these heterogeneous …

Regulation of breast cancer metastasis signaling by miRNAs

BJ Petri, CM Klinge - Cancer and metastasis reviews, 2020 - Springer
Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

The regulatory role of microRNAs in EMT and cancer

A Zaravinos - Journal of oncology, 2015 - Wiley Online Library
The epithelial to mesenchymal transition (EMT) is a powerful process in tumor invasion,
metastasis, and tumorigenesis and describes the molecular reprogramming and phenotypic …