In many eukaryotes, including mammals, plants, yeast, and insects, introns can increase
gene expression without functioning as a binding site for transcription factors. This …

Studies of promoters that largely regulate gene expression at the transcriptional level are
crucial for improving our basic understanding of gene regulation and will expand the toolbox …

The intron has been a big biological mystery since it was first discovered in several aspects.
First, all of the completely sequenced eukaryotes harbor introns in the genomic structure …

A picture is beginning to emerge from a variety of organisms that for a subset of genes, the
most important sequences that regulate expression are situated not in the promoter but …

Plants, unlike animals, exhibit a very high degree of plasticity in their growth and
development and employ diverse strategies to cope with the variations during diurnal cycles …

The intron–exon architecture of many eukaryotic genes raises the intriguing question of
whether this unique organization serves any function, or is it simply a result of the spread of …

Recombinant adeno-associated viruses (AAV) are under intensive investigation in
numerous clinical trials after they have emerged as a highly promising vector for human …

Throughout their lives, plants sense many developmental and environmental stimuli, and
activation of optimal responses against these stimuli requires extensive transcriptional …

The largest genus in the conifer family Pinaceae is Pinus, with over 100 species. The size
and complexity of their genomes (∼ 20–40 Gb, 2 n= 24) have delayed the arrival of a well …

Efficient nuclear transgene expression in the green microalga Chlamydomonas reinhardtii is
generally hindered by low transcription rates. Introns can increase transcript abundance by …