1Department of Cardiology, Division of Electrophysiology, University Heart Center Zurich,
Switzerland; 2Age-Related Health Care, Tallaght University Hospital/Department of …

The current manuscript is the second update of the original Practical Guide, published in
2013 [Heidbuchel et al. European Heart Rhythm Association Practical Guide on the use of …

Background Elderly patients with atrial fibrillation are at higher risk of both ischemic and
bleeding events compared to younger patients. In a prespecified analysis from the ENGAGE …

In the United States, the incidence rate of new or recurrent stroke is approximately 795 000
per year, and stroke prevalence for individuals over the age of 20 years is estimated at 6.5 …

ESC Guidelines 2721 the outcome of disease may be favourably influenced by the thorough
application of clinical recommendations. Thus, the task of writing guidelines covers not only …

Background Anticoagulants are more effective than antiplatelet agents at reducing stroke
risk in patients with atrial fibrillation, but whether this benefit outweighs the increased risk of …

Background Vitamin K antagonists reduce the risk of stroke in patients with atrial fibrillation
but are considered unsuitable in many patients, who usually receive aspirin instead. We …

Background—Nonvalvular atrial fibrillation is common in elderly patients, who face an
elevated risk of stroke but difficulty sustaining warfarin treatment. The oral factor Xa inhibitor …

Background—Warfarin is effective in the prevention of stroke in atrial fibrillation but is under
used in clinical care. Concerns exist that published rates of hemorrhage may not reflect real …

Background: In most patients with atrial fibrillation (AF) and stroke, there is thrombotic
embolization from the left atrial appendage (LAA). Percutaneous closure of the LAA is a …