Kidney fibrosis: from mechanisms to therapeutic medicines

R Huang, P Fu, L Ma - Signal Transduction and Targeted Therapy, 2023 - nature.com
Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Engineered exosomes from different sources for cancer-targeted therapy

M Zhang, S Hu, L Liu, P Dang, Y Liu, Z Sun… - Signal transduction and …, 2023 - nature.com
Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient
therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes …

Polydopamine nanoparticles targeting ferroptosis mitigate intervertebral disc degeneration via reactive oxygen species depletion, iron ions chelation, and GPX4 …

X Yang, Y Chen, J Guo, J Li, P Zhang… - Advanced …, 2023 - Wiley Online Library
Intervertebral disc degeneration (IVDD)‐induced lower back pain (LBP) is a common
problem worldwide. The underlying mechanism is partially accredited to ferroptosis, based …

Intelligent Micro‐/Nanorobots for Cancer Theragnostic

J Wang, Y Dong, P Ma, Y Wang, F Zhang… - Advanced …, 2022 - Wiley Online Library
Cancer is one of the most intractable diseases owing to its high mortality rate and lack of
effective diagnostic and treatment tools. Advancements in micro‐/nanorobot (MNR)‐assisted …

Recent progress in exosome research: isolation, characterization and clinical applications

X Wang, J **a, L Yang, J Dai, L He - Cancer Gene Therapy, 2023 - nature.com
Exosomes, a kind of nano-vesicles released by various cell types, carry a variety of “cargos”
including proteins, RNAs, DNAs and lipids. There is substantial evidence that exosomes are …

Targeted therapy for inflammatory diseases with mesenchymal stem cells and their derived exosomes: from basic to clinics

S Wang, B Lei, E Zhang, P Gong, J Gu… - International Journal …, 2022 - Taylor & Francis
Inflammation is a beneficial and physiological process, but there are a number of
inflammatory diseases which have detrimental effects on the body. In addition, the drugs …

Advancements in cell membrane camouflaged nanoparticles: a bioinspired platform for cancer therapy

N Dhas, MC García, R Kudarha, A Pandey… - Journal of Controlled …, 2022 - Elsevier
The idea of employing natural cell membranes as a coating medium for nanoparticles (NPs)
endows man-made vectors with natural capabilities and benefits. In addition to retaining the …

Novel tumor-targeting nanoparticles for cancer treatment—A review

AG Niculescu, AM Grumezescu - International Journal of Molecular …, 2022 - mdpi.com
Being one of the leading causes of death and disability worldwide, cancer represents an
ongoing interdisciplinary challenge for the scientific community. As currently used treatments …

[HTML][HTML] Small extracellular vesicles: non-negligible vesicles in tumor progression, diagnosis, and therapy

X Zhou, Y Jia, C Mao, S Liu - Cancer Letters, 2024 - Elsevier
Small extracellular vesicles (sEVs) such as exosomes are nanoscale membranous particles
(< 200 nm) that have emerged as crucial targets for liquid biopsy and as promising drug …

[HTML][HTML] Molecular targets, therapeutic agents and multitasking nanoparticles to deal with cancer stem cells: A narrative review

A Doustmihan, M Fathi, MA Mazloomi, A Salemi… - Journal of Controlled …, 2023 - Elsevier
There is increasing evidence that malignant tumors are initiated and maintained by a sub-
population of tumor cells that have similar biological properties to normal adult stem cells …