Transient receptor potential channels in the vasculature
The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …
[HTML][HTML] TRPC channels and store-operated Ca2+ entry
Store-operated calcium entry (SOCE) is a major mechanism for Ca2+ influx. Since SOCE
was first proposed two decades ago many techniques have been used in attempting to …
was first proposed two decades ago many techniques have been used in attempting to …
TRPC channels are necessary mediators of pathologic cardiac hypertrophy
X Wu, P Eder, B Chang… - Proceedings of the …, 2010 - National Acad Sciences
Pathologic hypertrophy of the heart is regulated through membrane-bound receptors and
intracellular signaling pathways that function, in part, by altering Ca2+ handling and Ca2+ …
intracellular signaling pathways that function, in part, by altering Ca2+ handling and Ca2+ …
TRPM4 in cardiac electrical activity
R Guinamard, P Bouvagnet, T Hof, H Liu… - Cardiovascular …, 2015 - academic.oup.com
TRPM4 forms a non-selective cation channel activated by internal Ca2+. Its functional
expression was demonstrated in cardiomyocytes of several mammalian species including …
expression was demonstrated in cardiomyocytes of several mammalian species including …
Hemorrhagic transformation after tissue plasminogen activator treatment in acute ischemic stroke
C Liu, J **e, S Sun, H Li, T Li, C Jiang, X Chen… - Cellular and molecular …, 2022 - Springer
Hemorrhagic transformation (HT) is a common complication after thrombolysis with
recombinant tissue-type plasminogen activator (rt-PA) in ischemic stroke. In this article …
recombinant tissue-type plasminogen activator (rt-PA) in ischemic stroke. In this article …
Trpm4 in cancer—a new potential drug target
A Borgström, C Peinelt, P Stokłosa - Biomolecules, 2021 - mdpi.com
Transient receptor potential melastatin 4 (TRPM4) is widely expressed in various organs
and associated with cardiovascular and immune diseases. Lately, the interest in studies on …
and associated with cardiovascular and immune diseases. Lately, the interest in studies on …
The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia
Background Harmful effects of activated microglia are due, in part, to the formation of
peroxynitrite radicals, which is attributable to the upregulation of inducible nitric oxide (NO) …
peroxynitrite radicals, which is attributable to the upregulation of inducible nitric oxide (NO) …
The non-selective monovalent cationic channels TRPM4 and TRPM5
R Guinamard, L Sallé, C Simard - Transient receptor potential channels, 2011 - Springer
Abstract Transient Receptor Potential (TRP) proteins are non-selective cationic channels
with a consistent Ca 2+-permeability, except for TRPM4 and TRPM5 that are not permeable …
with a consistent Ca 2+-permeability, except for TRPM4 and TRPM5 that are not permeable …
Trpm4 ion channels in pre-Bötzinger complex interneurons are essential for breathing motor pattern but not rhythm
Inspiratory breathing movements depend on pre-Bötzinger complex (preBötC) interneurons
that express calcium (Ca2+)-activated nonselective cationic current (I CAN) to generate …
that express calcium (Ca2+)-activated nonselective cationic current (I CAN) to generate …