The action potential of the squid giant axon is formed by just two voltage-dependent
conductances in the cell membrane, yet mammalian central neurons typically express more …

How an object is perceived depends on the temporal context in which it is encountered.
Sensory signals in the brain also depend on temporal context, a phenomenon often referred …

Bacterial adaptive immunity uses CRISPR (clustered regularly interspaced short palindromic
repeats)–associated (Cas) proteins together with CRISPR transcripts for foreign DNA …

The fear responses to environmental threats play a fundamental role in survival. Little is
known about the neural circuits specifically processing threat-relevant sensory information in …

Exome and targeted sequencing have revolutionized clinical diagnosis. This has been
particularly striking in epilepsy and neurodevelopmental disorders, for which new genes or …

Although K+ channels activated by Ca 2+ have long been known to shape neuronal
excitability, evidence is accumulating that K+ channels sensitive to intracellular Na+, termed …

Perceptual bistability occurs when a physical stimulus gives rise to two distinct
interpretations that alternate irregularly. Noise and adaptation processes are two possible …

We performed a systematic analysis of phase locking in pairs of electrically coupled
neocortical fast-spiking (FS) and low-threshold-spiking (LTS) interneurons and in a …

The Slack and Slick genes encode potassium channels that are very widely expressed in
the central nervous system. These channels are activated by elevations in intracellular …

Models of cortical dynamics often assume a homogeneous connectivity structure. However,
we show that heterogeneous input connectivity can prevent the dynamic balance between …