Functional analysis of circulating tumour cells: the KEY to understand the biology of the metastatic cascade

Z Eslami-S, LE Cortes-Hernandez, F Thomas… - British Journal of …, 2022 - nature.com
Metastasis formation is the main cause of cancer-related death in patients with solid
tumours. At the beginning of this process, cancer cells escape from the primary tumour to the …

The metastatic cascade as the basis for liquid biopsy development

Z Eslami-S, LE Cortés-Hernández… - Frontiers in …, 2020 - frontiersin.org
The metastatic cascade describes the process whereby aggressive cancer cells leave the
primary tumor, travel through the bloodstream, and eventually reach distant organs to …

Identifying key questions in the ecology and evolution of cancer

AM Dujon, A Aktipis, C Alix‐Panabières… - Evolutionary …, 2021 - Wiley Online Library
The application of evolutionary and ecological principles to cancer prevention and
treatment, as well as recognizing cancer as a selection force in nature, has gained impetus …

Do malignant cells sleep at night?

LE Cortés-Hernández, Z Eslami-S, AM Dujon… - Genome Biology, 2020 - Springer
Biological rhythms regulate the biology of most, if not all living creatures, from whole
organisms to their constitutive cells, their microbiota, and also parasites. Here, we present …

The genomic processes of biological invasions: From invasive species to cancer metastases and back again

F Neinavaie, A Ibrahim-Hashim, AM Kramer… - Frontiers in Ecology …, 2021 - frontiersin.org
The concept of invasion is useful across a broad range of contexts, spanning from the fine
scale landscape of cancer tumors up to the broader landscape of ecosystems. Invasion …

Evo-devo perspectives on cancer

AM Nedelcu - Essays in Biochemistry, 2022 - portlandpress.com
The integration of evolutionary and developmental approaches into the field of evolutionary
developmental biology has opened new areas of inquiry—from understanding the evolution …

Tumors are evolutionary island-like ecosystems

A Chroni, S Kumar - Genome Biology and Evolution, 2021 - academic.oup.com
Integration of ecological and evolutionary features has begun to understand the interplay of
tumor heterogeneity, microenvironment, and metastatic potential. Develo** a theoretical …

Modeling cancer's ecological and evolutionary dynamics

A Bukkuri, KJ Pienta, I Hockett, RH Austin… - Medical Oncology, 2023 - Springer
In this didactic paper, we present a theoretical modeling framework, called the G-function,
that integrates both the ecology and evolution of cancer to understand oncogenesis. The G …

Does cancer biology rely on Parrondo's principles?

JP Capp, AM Nedelcu, AM Dujon, B Roche, F Catania… - Cancers, 2021 - mdpi.com
Simple Summary Parrondo's paradox, whereby losing strategies or deleterious effects can
combine to provide a winning outcome, has been increasingly applied by biologists to …

The conditional defector strategies can violate the most crucial supporting mechanisms of cooperation

AM Ibrahim - Scientific Reports, 2022 - nature.com
Cooperation is essential for all domains of life. Yet, ironically, it is intrinsically vulnerable to
exploitation by cheats. Hence, an explanatory necessity spurs many evolutionary biologists …