Many past and recent advances in the field of iron metabolism have relied upon the
discovery of divalent metal transporter 1, DMT1 in 1997. DMT1 is the major iron transporter …

Metal nanoparticles used as antifungals have increased the occurrence of fungal–metal
interactions. However, there is a lack of knowledge about how these interactions cause …

Newly synthesized transmembrane proteins undergo a series of steps to ensure that only
the required amount of correctly folded protein is localized to the membrane. The regulation …

Members of the HECT family of E3 ubiquitin-protein ligases are characterized by a C-
terminal HECT domain that catalyzes the covalent attachment of ubiquitin to substrate …

E3 ligases are a class of enzymes that can transfer ubiquitin to substrates for their
degradation, which are of importance in cellular homeostasis. Since many oncogenic or …

Myc oncoproteins are commonly upregulated in human cancers of different organ origins,
stabilized by Aurora A, degraded through ubiquitin–proteasome pathway-mediated …

Autophagy represents a fundamental mechanism for maintaining cell survival and tissue
homeostasis in response to physiological and pathological stress. Autophagy initiation …

Autophagy is an intracellular degradation pathway whose levels are tightly controlled to
secure cell homeostasis. Unc-51–like kinase 1 (ULK1) is a conserved serine–threonine …

Abstract NEDD4-2 (also known as NEDD4L, neural precursor cell expressed
developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family …

UBR box E3 ligases, also called N-recognins, are integral components of the N-degron
pathway. Representative N-recognins include UBR1, UBR2, UBR4, and UBR5, and they …