This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

The endogenous cannabinoid transmitter system regulates synaptic transmission
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …

The endocannabinoid system (ECS) comprises two cognate endocannabinoid receptors
referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro …

A plethora of studies indicate the important role of cAMP and cGMP cascades in neuronal
plasticity and memory function. As a result, altered cyclic nucleotide signaling has been …

Neuropathic pain is a chronic pain caused by central and peripheral nerve injury, long-term
diabetes or treatment with chemotherapy drugs, and it is dissimilar to other chronic pain …

The second messenger cAMP is an important determinant of synaptic plasticity that is
associated with enhanced neurotransmitter release. Long-term potentiation (LTP) at parallel …

There has been a significant increase in the consumption of cannabis for both recreational
and medicinal purposes in recent years, and its use can have long-term consequences on …

Long-term synaptic plasticity is critical for adaptive function of the brain, but presynaptic
mechanisms of functional plasticity remain poorly understood. Here, we show that changes …

Type 1 cannabinoid receptors (CB1Rs) are expressed in major retinal neurons within the
rod-pathway suggesting a role in regulating night visual processing, but the underlying …

The leading cause of steroid-induced femoral head osteonecrosis (ONFH) is the imbalance
of bone homeostasis. Bone marrow-derived mesenchymal stem cell (BMSC) differentiation …