Post-transcriptional regulation is a fundamental process in gene expression that has a role
in diverse cellular processes, including immune responses. A core concept underlying post …

The kidneys are life-sustaining organs that are vital to removing waste from our body.
Because of their anatomic position and high blood flow, the kidneys are vulnerable to …

IL17 is required for the initiation and progression of pancreatic cancer, particularly in the
context of inflammation, as previously shown by genetic and pharmacological approaches …

Autoantibody-mediated glomerulonephritis (AGN) arises from dysregulated renal
inflammation, with urgent need for improved treatments. IL-17 is implicated in AGN and …

Kidney disease represents a major medical and economic burden for which improved
treatments are urgently needed. Emerging data have implicated Th17 cells and IL-17 …

Systemic lupus erythematosus is an autoimmune disease that results in immune-mediated
damage to kidneys and other organs. We investigated the role of response gene to …

Lupus nephritis (LN) is a type of immunological complex glomerulonephritis characterized
by chronic renal inflammation which is exacerbated by infiltrating leukocytes and fueled by a …

Excessive inflammation can cause tissue damage and autoimmunity, sometimes
accompanied by severe morbidity or mortality. Numerous negative feedback mechanisms …

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second leading
cause of cancer-related deaths. PDAC is characterized by the early establishment of a …