Although elevated cholesterol and other recognised cardiovascular risk factors are important
in the development of coronary artery disease (CAD) and heart attack, the susceptibility of …

The zinc-finger transcription factor KLF2 transduces the physical forces exerted by blood
flow into molecular signals responsible for a wide range of biological responses. Following …

Objective The vascular system is adapted to specific functions in different tissues and
organs. Vascular endothelial cells are important elements of this adaptation, leading to the …

A critical challenge to the success of biodegradable vascular grafts is the establishment of a
healthy endothelium. To establish this monolayer of endothelial cells (ECs), a variety of …

Bioengineered grafts have the potential to overcome the limitations of autologous and non-
resorbable synthetic vessels as vascular substitutes. However, one of the challenges in …

Background Oxidative stress is recognized as a key factor in the induction of endothelial
dysfunction in diabetes. However, the specific mechanisms have not been fully elucidated …

Biomechanics affect early cardiac development, from loo** to the development of
chambers and valves. Hemodynamic forces are essential for proper cardiac development …

The blood flow through vessels produces a tangential, or shear, stress sensed by their
innermost layer (ie, endothelium) and representing a major hemodynamic force. In humans …

In regenerative medicine, autologous peripheral blood derived endothelial colony forming
cells (PB-derived ECFC) represent a promising source of endothelial cells (EC) for pre …

Growth-restricted fetuses with absent or reversed end-diastolic velocities in the umbilical
artery are at substantially increased risk for adverse perinatal and long-term outcome, even …