Small and large animal models in cardiac contraction research: advantages and disadvantages
N Milani-Nejad, PML Janssen - Pharmacology & therapeutics, 2014 - Elsevier
The mammalian heart is responsible for not only pum** blood throughout the body but
also adjusting this pum** activity quickly depending upon sudden changes in the …
also adjusting this pum** activity quickly depending upon sudden changes in the …
KATP Channels in the Cardiovascular System
MN Foster, WA Coetzee - Physiological reviews, 2016 - journals.physiology.org
KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …
electrophysiological methods has allowed for a detailed characterization of KATP channels …
Atrial fibrillation driven by micro-anatomic intramural re-entry revealed by simultaneous sub-epicardial and sub-endocardial optical map** in explanted human …
Aims The complex architecture of the human atria may create physical substrates for
sustained re-entry to drive atrial fibrillation (AF). The existence of sustained, anatomically …
sustained re-entry to drive atrial fibrillation (AF). The existence of sustained, anatomically …
Cardiac mechano-gated ion channels and arrhythmias
Mechanical forces will have been omnipresent since the origin of life, and living organisms
have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The …
have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The …
ATP-Sensitive potassium channels and their physiological and pathophysiological roles.
ATP sensitive potassium channels (KATP) are so named because they open as cellular ATP
levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to …
levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to …
KATP Channels and Cardiovascular Disease: Suddenly a Syndrome
CG Nichols, GK Singh, DK Grange - Circulation research, 2013 - Am Heart Assoc
ATP-sensitive potassium (KATP) channels were first discovered in the heart 30 years ago.
Reconstitution of KATP channel activity by coexpression of members of the pore-forming …
Reconstitution of KATP channel activity by coexpression of members of the pore-forming …
Intermittent drivers anchoring to structural heterogeneities as a major pathophysiological mechanism of human persistent atrial fibrillation
M Haissaguerre, AJ Shah, H Cochet… - The Journal of …, 2016 - Wiley Online Library
The mechanisms responsible for perpetuation of human persistent atrial fibrillation (AF) are
controversial and probably vary between individuals. A wide spectrum of mechanisms have …
controversial and probably vary between individuals. A wide spectrum of mechanisms have …
Profibrotic, electrical, and calcium-handling remodeling of the atria in heart failure patients with and without atrial fibrillation
Atrial fibrillation (AF) and heart failure (HF) are common cardiovascular diseases that often
co-exist. Animal models have suggested complex AF-promoting atrial structural, electrical …
co-exist. Animal models have suggested complex AF-promoting atrial structural, electrical …
Conduction remodeling in human end-stage nonischemic left ventricular cardiomyopathy
Background—Several arrhythmogenic mechanisms have been inferred from animal heart
failure models. However, the translation of these hypotheses is difficult because of the lack …
failure models. However, the translation of these hypotheses is difficult because of the lack …
Human organotypic cultured cardiac slices: new platform for high throughput preclinical human trials
Translation of novel therapies from bench to bedside is hampered by profound disparities
between animal and human genetics and physiology. The ability to test for efficacy and …
between animal and human genetics and physiology. The ability to test for efficacy and …