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Lactate metabolism in human health and disease
X Li, Y Yang, B Zhang, X Lin, X Fu, Y An… - Signal transduction and …, 2022 - nature.com
The current understanding of lactate extends from its origins as a byproduct of glycolysis to
its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate …
its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate …
Amino acid metabolism in tumor biology and therapy
J Chen, L Cui, S Lu, S Xu - Cell Death & Disease, 2024 - nature.com
Amino acid metabolism plays important roles in tumor biology and tumor therapy.
Accumulating evidence has shown that amino acids contribute to tumorigenesis and tumor …
Accumulating evidence has shown that amino acids contribute to tumorigenesis and tumor …
[HTML][HTML] Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα
D Guo, Y Tong, X Jiang, Y Meng, H Jiang, L Du, Q Wu… - Cell metabolism, 2022 - cell.com
High expression of PD-L1 in tumor cells contributes to tumor immune evasion. However,
whether PD-L1 expression in tumor cells is regulated by the availability of nutrients is …
whether PD-L1 expression in tumor cells is regulated by the availability of nutrients is …
Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications
Q Zhong, X ** the tumor microenvironment
More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …
tumors depend on gene mutation and tumor heterogeneity. The most important …
Copper homeostasis and cuproptosis in cancer immunity and therapy
WQ Liu, WR Lin, L Yan, WH Xu… - Immunological reviews, 2024 - Wiley Online Library
Copper is an essential nutrient for maintaining enzyme activity and transcription factor
function. Excess copper results in the aggregation of lipoylated dihydrolipoamide S …
function. Excess copper results in the aggregation of lipoylated dihydrolipoamide S …
Role of hypoxia in the tumor microenvironment and targeted therapy
G Chen, K Wu, H Li, D **a, T He - Frontiers in oncology, 2022 - frontiersin.org
Tumor microenvironment (TME), which is characterized by hypoxia, widely exists in solid
tumors. As a current research hotspot in the TME, hypoxia is expected to become a key …
tumors. As a current research hotspot in the TME, hypoxia is expected to become a key …
OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB
W Ma, Y Sun, R Yan, P Zhang, S Shen, H Lu, Z Zhou… - Molecular Cell, 2024 - cell.com
Metabolic reprogramming is an important feature of cancers that has been closely linked to
post-translational protein modification (PTM). Lysine succinylation is a recently identified …
post-translational protein modification (PTM). Lysine succinylation is a recently identified …
O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1
Q Zhu, H Zhou, L Wu, Z Lai, D Geng, W Yang… - Nature Chemical …, 2022 - nature.com
Oncogenic Kras-activated pancreatic ductal adenocarcinoma (PDAC) cells highly rely on an
unconventional glutamine catabolic pathway to sustain cell growth. However, little is known …
unconventional glutamine catabolic pathway to sustain cell growth. However, little is known …
m5C-methylated lncRNA NR_033928 promotes gastric cancer proliferation by stabilizing GLS mRNA to promote glutamine metabolism reprogramming
L Fang, H Huang, J Lv, Z Chen, C Lu, T Jiang… - Cell Death & …, 2023 - nature.com
Abstract Abnormal 5-methylcytosine (m5C) methylation has been proved to be closely
related to gastric carcinogenesis, progression, and prognosis. Dysregulated long noncoding …
related to gastric carcinogenesis, progression, and prognosis. Dysregulated long noncoding …