Life science research is advancing rapidly in the 21st century. Many innovative technologies
and methodologies are being applied in various fields of the life sciences to reveal how …

Cancer stem cells (CSCs) represent both a key driving force and therapeutic target of
tumoral carcinogenesis, tumor evolution, progression, and recurrence. CSC-guided tumor …

A novel DNA hybridization optical fiber sensor with temperature and pH compensation for
detecting a common lung cancer gene of epidermal growth factor receptor (EGFR) gene was …

The circulating tumor DNA (ctDNA) is a crucial cancer marker, its sensitive monitoring is
useful for early diagnose and therapy of tumor-related diseases. Herein, a bipedal DNA …

Accurate identification of single-nucleotide mutations in circulating tumor DNA (ctDNA) is
critical for cancer surveillance and cell biology research. However, achieving precise and …

The circulating cell-free nucleic acids (ccfNAs) consist of a heterogenous cocktail of both
single (ssNA) and double-stranded (dsNA) nucleic acids. These ccfNAs are secreted into the …

Nucleic acid‐based molecular recognition plays crucial roles in various fields like
biosensing and disease diagnostics. To achieve optimal detection and analysis, it is …

The sensitive and accurate detection of biomarkers plays an important role in clinical
diagnosis and drug discovery. Currently, amplification-based methods for biomarker …

MicroRNAs (miRNAs) are short non-coding RNAs that play an important role in regulating
gene expression. Since miRNAs are abnormally expressed in various cancers, they are …

The most well-studied epigenetic marker in humans is the 5-methyl modification of cytosine
in DNA, which has great potential as a disease biomarker. Currently, quantification of DNA …