The brain is a highly energy-demanding organ and requires bioenergetic adaptability to
balance normal activity with pathophysiological fuelling of spontaneous recurrent seizures …

Neuroinflammation and epilepsy are interconnected. Brain inflammation promotes neuronal
hyper-excitability and seizures, and dysregulation in the glia immune-inflammatory function …

Mitochondria are major sources of reactive oxygen species (ROS) within the cell and are
especially vulnerable to oxidative stress. Oxidative damage to mitochondria results in …

Glutamine is an essential cerebral metabolite. Several critical brain processes are directly
linked to glutamine, including ammonia homeostasis, energy metabolism and …

Self-assembly of hydrogels for mechanical support and drug delivery has been extensively
researched in traumatic brain injury (TBI), where treatment options are limited. The chief …

In this retrospective, multicentre, observational cohort study, we sought to determine the
clinical, radiological, EEG, genetics and neuropathological characteristics of mitochondrial …

Astrocytes play essential roles in development, homeostasis, injury, and repair of the central
nervous system (CNS). Their development is tightly regulated by distinct spatial and …

Strict homeostatic control of pH in both intra-and extracellular compartments of the brain is
fundamentally important, primarily due to the profound impact of free protons ([H+]) on …

Epilepsy affects about 1% of the population and approximately 30% of epileptic patients are
resistant to current antiepileptic drugs. As a hallmark in epileptic tissue, many of the epileptic …

Animal models contribute greatly to our understanding of brain development and function as
well as its dysfunction in neurological diseases. Epilepsy research is a very good example of …