Liver cancer remains a global health challenge, with an estimated incidence of> 1 million
cases by 2025. Hepatocellular carcinoma (HCC) is the most common form of liver cancer …

Hepatocellular carcinoma (HCC) is an aggressive disease with a poor clinical outcome. The
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …

Background & Aims Hepatocellular carcinoma (HCC), a leading cause of cancer-related
death, is associated with viral hepatitis, non-alcoholic steatohepatitis (NASH), and alcohol …

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …

Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related
(ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression …

Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and
metabolic adaptation, has been implicated as a process that regulates cancer. Although …

Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …

Calcium (Ca2+) is a major second messenger in cells and is essential for the fate and
survival of all higher organisms. Different Ca2+ channels, pumps, or exchangers regulate …

Autophagy causes the breakdown of damaged proteins and organelles to their constituent
components. The phosphatidylinositol 3‐kinase (PI3K) pathway played an important role in …

Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a
molecular lynchpin that links persistent infections and chronic inflammation to increased …