Drug nanocrystals for active tumor-targeted drug delivery
L Lu, Q Xu, J Wang, S Wu, Z Luo, W Lu - Pharmaceutics, 2022 - mdpi.com
Drug nanocrystals, which are comprised of active pharmaceutical ingredients and only a
small amount of essential stabilizers, have the ability to improve the solubility, dissolution …
small amount of essential stabilizers, have the ability to improve the solubility, dissolution …
Recent applications of electrical, centrifugal, and pressurised emerging technologies for fibrous structure engineering in drug delivery, regenerative medicine and …
Advancements in technology and material development in recent years has led to significant
breakthroughs in the remit of fiber engineering. Conventional methods such as wet spinning …
breakthroughs in the remit of fiber engineering. Conventional methods such as wet spinning …
Degrees of order: A comparison of nanocrystal and amorphous solids for poorly soluble drugs
L Peltonen, CJ Strachan - International Journal of Pharmaceutics, 2020 - Elsevier
Poor aqueous solubility is currently a prevalent issue in the development of small molecule
pharmaceuticals. Several methods are possible for improving the solubility, dissolution rate …
pharmaceuticals. Several methods are possible for improving the solubility, dissolution rate …
Nanocrystals technologies in biomedical science: bench to beside the clinic
The pharmaceutical industry is grappling with a pressing crisis in drug development,
characterized by soaring R&D costs, setbacks in blockbuster drug development due to poor …
characterized by soaring R&D costs, setbacks in blockbuster drug development due to poor …
Nondestructive investigation of the agglomeration process for nanosuspensions via NMR relaxation of water molecules
K Okada, Y Hayashi, S Kumada, Y Onuki - European Journal of …, 2021 - Elsevier
This study investigated an agglomeration of nanoparticles in a suspension using nuclear
magnetic resonance (NMR) relaxation. The nanosuspension was prepared by wet bead …
magnetic resonance (NMR) relaxation. The nanosuspension was prepared by wet bead …
Characterizing and exploring the differences in dissolution and stability between crystalline solid dispersion and amorphous solid dispersion
X Wang, L Zhang, D Ma, X Tang, Y Zhang, T Yin… - Aaps …, 2020 - Springer
Solid dispersion is one of the most effective ways to improve the dissolution of insoluble
drugs. When the carrier can highly disperse the drug, it will increase the wettability of the …
drugs. When the carrier can highly disperse the drug, it will increase the wettability of the …
Pharma 4.0-artificially intelligent digital twins for solidified nanosuspensions
C Davidopoulou, A Ouranidis - Pharmaceutics, 2022 - mdpi.com
Digital twins capacitate the industry 4.0 paradigm by predicting and optimizing the
performance of physical assets of interest, mirroring a realistic in-silico representation of …
performance of physical assets of interest, mirroring a realistic in-silico representation of …
Antibacterial activities of physiologically stable, self-assembled peptide nanoparticles
In this study, we report that host defense protein-derived ten amino acid long disulfide-linked
peptides self-assemble in the form of β-sheets and β-turns, and exhibit concentration …
peptides self-assemble in the form of β-sheets and β-turns, and exhibit concentration …
A novel interfacial thermodynamic model for predicting solubility of nanoparticles coated by stabilizers
K Ge, Y Ji, X Lu - Chinese Journal of Chemical Engineering, 2021 - Elsevier
To improve the stability of nanoparticles in aqueous solution, polymer or surfactant, etc. are
often added in solutions during the preparation process of nanoparticles, which can induce …
often added in solutions during the preparation process of nanoparticles, which can induce …
Monitoring the Degradation of Metal‐Organic Framework Drug Nanocarriers by In‐Situ NMR Spectroscopy
An accurate characterization methodology is indispensable to design nanoparticle‐based
drug delivery system (DDS) adapted to specific diseases and therapies. However …
drug delivery system (DDS) adapted to specific diseases and therapies. However …