Brown and beige fat: development, function and therapeutic potential

M Harms, P Seale - Nature medicine, 2013 - nature.com
Adipose tissue, best known for its role in fat storage, can also suppress weight gain and
metabolic disease through the action of specialized, heat-producing adipocytes. Brown …

Health benefits of exercise

GN Ruegsegger, FW Booth - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
Overwhelming evidence exists that lifelong exercise is associated with a longer health span,
delaying the onset of 40 chronic conditions/diseases. What is beginning to be learned is the …

Metabolic flexibility as an adaptation to energy resources and requirements in health and disease

RL Smith, MR Soeters, RCI Wüst… - Endocrine …, 2018 - academic.oup.com
The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …

Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases

RR Kalyani, M Corriere, L Ferrucci - The lancet Diabetes & …, 2014 - thelancet.com
The term sarcopenia refers to the loss of muscle mass that occurs with ageing. On the basis
of study results showing that muscle mass is only moderately related to functional outcomes …

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

RC Laker, JC Drake, RJ Wilson, VA Lira… - Nature …, 2017 - nature.com
Mitochondrial health is critical for skeletal muscle function and is improved by exercise
training through both mitochondrial biogenesis and removal of damaged/dysfunctional …

Mitochondrial disease

AHV Schapira - The Lancet, 2006 - thelancet.com
Defects of mitochondrial metabolism cause a wide range of human diseases that include
examples from all medical subspecialties. This review updates the topic of mitochondrial …

High-intensity interval running is perceived to be more enjoyable than moderate-intensity continuous exercise: implications for exercise adherence

JD Bartlett, GL Close, DPM MacLaren… - Journal of sports …, 2011 - Taylor & Francis
The aim of this study was to objectively quantify ratings of perceived enjoyment using the
Physical Activity Enjoyment Scale following high-intensity interval running versus moderate …

[HTML][HTML] Mitochondrial dysfunction in metabolic syndrome

P Prasun - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2020 - Elsevier
Metabolic syndrome is co-occurrence of obesity, insulin resistance, atherogenic
dyslipidemia (high triglyceride, low high density lipoprotein cholesterol), and hypertension. It …

Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling

Z Radak, Z Zhao, E Koltai, H Ohno… - Antioxidants & redox …, 2013 - liebertpub.com
The complexity of human DNA has been affected by aerobic metabolism, including
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …

The crosstalk between the gut microbiota and mitochondria during exercise

A Clark, N Mach - Frontiers in physiology, 2017 - frontiersin.org
Many physiological changes occur in response to endurance exercise in order to adapt to
the increasing energy needs, mitochondria biogenesis, increased reactive oxygen species …