Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting
materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are …

Dihydropyrimidinones are heterocycles with a pyrimidine moiety in the ring nucleus, which,
in recent decades, have aroused interest in medicinal chemistry due to alleged versatile …

Heat shock protein 70 (Hsp70a) is a molecular chaperone that is expressed in response to
stress. In this role, Hsp70 binds to its protein substrates and stabilize them against …

Since the disclosure of Biginelli reaction by the chemist Pietro Biginelli, functionalized 3, 4-
dihydropyrimidin-2 (1H)-ones/thiones (DHPMs) have emerged as prototypes for the design …

The design and synthesis of novel adenosine-derived inhibitors of HSP70, guided by
modeling and X-ray crystallographic structures of these compounds in complex with …

Molecular chaperones HSP90 and HSP70 are essential regulators of the folding and
activation of a disparate ensemble of client proteins. They function through ATP hydrolysis …

Heat shock protein 70 (Hsp70) is a highly conserved molecular chaperone that plays
multiple roles in protein homeostasis. In these various tasks, the activity of Hsp70 is shaped …

This review covers up to 2010 and some available references of 2011 of synthetic advances
in the Biginelli reaction, including recent mechanistic advances, new building blocks, new …

Plasmodium falciparum, the Apicomplexan parasite that is responsible for the most lethal
forms of human malaria, is exposed to radically different environments and stress factors …

The molecular chaperone, heat shock protein 70 (Hsp70), acts at multiple steps in a
protein's life cycle, including during the processes of folding, trafficking, remodeling and …