Cytokines in inflammatory disease

S Kany, JT Vollrath, B Relja - International journal of molecular sciences, 2019 - mdpi.com
This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines.
Numerous studies have implicated that inflammatory cytokines exert important effects with …

Macrophages in intestinal homeostasis and inflammatory bowel disease

LM Hegarty, GR Jones, CC Bain - Nature Reviews Gastroenterology & …, 2023 - nature.com
Macrophages are essential for the maintenance of intestinal homeostasis, yet appear to be
drivers of inflammation in the context of inflammatory bowel disease (IBD). How these …

The enteric nervous system relays psychological stress to intestinal inflammation

KM Schneider, N Blank, Y Alvarez, K Thum… - Cell, 2023 - cell.com
Mental health profoundly impacts inflammatory responses in the body. This is particularly
apparent in inflammatory bowel disease (IBD), in which psychological stress is associated …

Large-scale plasma proteomics comparisons through genetics and disease associations

GH Eldjarn, E Ferkingstad, SH Lund, H Helgason… - Nature, 2023 - nature.com
High-throughput proteomics platforms measuring thousands of proteins in plasma combined
with genomic and phenotypic information have the power to bridge the gap between the …

Host–microbiota interactions in inflammatory bowel disease

R Caruso, BC Lo, G Núñez - Nature Reviews Immunology, 2020 - nature.com
The mammalian intestine is colonized by trillions of microorganisms that have co-evolved
with the host in a symbiotic relationship. The presence of large numbers of symbionts near …

Biology and therapeutic potential of interleukin-10

M Saraiva, P Vieira, A O'garra - Journal of Experimental Medicine, 2019 - rupress.org
The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from
over-exuberant responses to pathogens and microbiota, while playing important roles in …

Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD

YR Na, M Stakenborg, SH Seok… - … reviews Gastroenterology & …, 2019 - nature.com
Macrophages are the gatekeepers of intestinal immune homeostasis as they discriminate
between innocuous antigens and potential pathogens to maintain oral tolerance. However …

Food components and dietary habits: keys for a healthy gut microbiota composition

E Rinninella, M Cintoni, P Raoul, LR Lopetuso… - Nutrients, 2019 - mdpi.com
The gut microbiota is a changing ecosystem, containing trillions of bacteria, continuously
shaped by many factors, such as dietary habits, seasonality, lifestyle, stress, antibiotics use …

IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation

W Ouyang, A O'Garra - Immunity, 2019 - cell.com
Cytokines are among the most important effector and messenger molecules in the immune
system. They profoundly participate in immune responses during infection and inflammation …

Targeting immune cell circuits and trafficking in inflammatory bowel disease

MF Neurath - Nature immunology, 2019 - nature.com
Inflammatory bowel diseases (IBDs) such as Crohn's disease and ulcerative colitis are
characterized by uncontrolled activation of intestinal immune cells in a genetically …