Emerging evidence of pathological roles of very-low-density lipoprotein (VLDL)
JK Huang, HC Lee - International journal of molecular sciences, 2022 - mdpi.com
Embraced with apolipoproteins (Apo) B and Apo E, triglyceride-enriched very-low-density
lipoprotein (VLDL) is secreted by the liver into circulation, mainly during post-meal hours …
lipoprotein (VLDL) is secreted by the liver into circulation, mainly during post-meal hours …
Functional role of PPARs in ruminants: Potential targets for fine‐tuning metabolism during growth and lactation
Characterization and biological roles of the peroxisome proliferator‐activated receptor
(PPAR) isotypes are well known in monogastrics, but not in ruminants. However, a wealth of …
(PPAR) isotypes are well known in monogastrics, but not in ruminants. However, a wealth of …
Obesity, diabetes, and cardiovascular diseases: a compendium
1704 Circulation Research May 27, 2016 of epigenetic mechanisms contributing to
macrovascular disease in diabetes. The authors highlight the recent identification of …
macrovascular disease in diabetes. The authors highlight the recent identification of …
Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply
Background: Adrenergic activation of brown adipocytes mobilizes fatty acids for oxidation
and promotes transcription of oxidative genes. Results: Activation of adipocyte lipases …
and promotes transcription of oxidative genes. Results: Activation of adipocyte lipases …
Endogenous ligands for nuclear receptors: digging deeper
Nuclear receptors (NRs) are hormone-sensing transcription factors that translate dietary or
endocrine signals into changes in gene expression. Therefore, the adoption of orphan NRs …
endocrine signals into changes in gene expression. Therefore, the adoption of orphan NRs …
Gluten-free diet reduces adiposity, inflammation and insulin resistance associated with the induction of PPAR-alpha and PPAR-gamma expression
FLP Soares, R de Oliveira Matoso, LG Teixeira… - the Journal of nutritional …, 2013 - Elsevier
Gluten exclusion (protein complex present in many cereals) has been proposed as an
option for the prevention of diseases other than coeliac disease. However, the effects of …
option for the prevention of diseases other than coeliac disease. However, the effects of …
Postprandial lipoproteins and the molecular regulation of vascular homeostasis
KM Botham, CPD Wheeler-Jones - Progress in Lipid Research, 2013 - Elsevier
Blood levels of triglyceride-rich lipoproteins (TRL) increase postprandially, and a delay in
their clearance results in postprandial hyperlipidemia, an important risk factor in …
their clearance results in postprandial hyperlipidemia, an important risk factor in …
The PPAR-RXR transcriptional complex in the vasculature: energy in the balance
J Plutzky - Circulation research, 2011 - Am Heart Assoc
The peroxisome proliferator-activated receptors (PPARs) and the retinoid X receptors
(RXRs) are ligand-activated transcription factors that coordinately regulate gene expression …
(RXRs) are ligand-activated transcription factors that coordinately regulate gene expression …
Lipoprotein lipase: from gene to atherosclerosis
Y Li, PP He, DW Zhang, XL Zheng, FS Cayabyab… - Atherosclerosis, 2014 - Elsevier
Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism and responsible for catalyzing
lipolysis of triglycerides in lipoproteins. LPL is produced mainly in adipose tissue, skeletal …
lipolysis of triglycerides in lipoproteins. LPL is produced mainly in adipose tissue, skeletal …
Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice
PPARα (PPARA), expressed in most oxidative tissues, is a major regulator of lipid
homeostasis; hepatic PPARA plays a critical role during the adaptive fasting response by …
homeostasis; hepatic PPARA plays a critical role during the adaptive fasting response by …