DNA-based biosensors have been widely used for its stable chemical properties, cost-
effectiveness, and easy modification. G-quadruplex (G4) DNA has attracted growing interest …

Guanine and related nucleobases such as guanosine, deoxyguanosine and isoguanosine
are notable molecular tools for designing functional supramolecular assemblies. This …

Lead (Pb) is a highly toxic heavy metal of great environmental and health concerns, and
interestingly Pb 2+ has played important roles in nucleic acids chemistry. Since 2000, using …

Abstract G-quadruplex (G4)/hemin DNAzyme is promising horseradish peroxidase (HRP)-
mimic candidate in the biological field. However, its relatively unsatisfactory catalytic …

DNAzyme-based chemiluminescence assay exhibits excellent performance in bioanalysis
but their operation in acid conditions remains challengeable. Herein, we constructed an acid …

G-quadruplex/hemin (G4/hemin) DNAzymes are biosensing systems, but their application
remains limited by an overall low activity and a rather high level of unwarranted background …

Chimeric peptide-DNAzyme (CPDzyme) is a novel artificial peroxidase that relies on the
covalent assembly of DNA, peptides, and an enzyme cofactor in a single scaffold. An …

Here we develop robust noncovalent spherical nucleic acid enzymes (SNAzymes) for direct
electrochemiluminescence (ECL) detection of acute myocardial infarction (AMI) related …

Exosomes are considered as potential biomarkers that can reflect information from their
parent cell-associated cancer microenvironment. Recently, aptasensors have been widely …

Early diagnosis of parasitic diseases can dramatically alleviate medical, economic, and
social burdens. Herein, we report a sensitive and label-free assay for diagnosing single …