miRNA: a promising therapeutic target in cancer
microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by
complementarity pairing. Since discovery, they have been reported to be involved in a …
complementarity pairing. Since discovery, they have been reported to be involved in a …
Non-coding RNAs in human disease
M Esteller - Nature reviews genetics, 2011 - nature.com
The relevance of the non-coding genome to human disease has mainly been studied in the
context of the widespread disruption of microRNA (miRNA) expression and function that is …
context of the widespread disruption of microRNA (miRNA) expression and function that is …
[HTML][HTML] Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis
SA Melo, H Sugimoto, JT O'Connell, N Kato… - Cancer cell, 2014 - cell.com
Exosomes are secreted by all cell types and contain proteins and nucleic acids. Here, we
report that breast cancer associated exosomes contain microRNAs (miRNAs) associated …
report that breast cancer associated exosomes contain microRNAs (miRNAs) associated …
MicroRNAs and other non-coding RNAs as targets for anticancer drug development
The first cancer-targeted microRNA (miRNA) drug—MRX34, a liposome-based miR-34
mimic—entered Phase I clinical trials in patients with advanced hepatocellular carcinoma in …
mimic—entered Phase I clinical trials in patients with advanced hepatocellular carcinoma in …
The role and mechanisms of action of microRNAs in cancer drug resistance
W Si, J Shen, H Zheng, W Fan - Clinical epigenetics, 2019 - Springer
MicroRNAs (miRNAs) are small non-coding RNAs with a length of about 19–25 nt, which
can regulate various target genes and are thus involved in the regulation of a variety of …
can regulate various target genes and are thus involved in the regulation of a variety of …
The microcosmos of cancer
A Lujambio, SW Lowe - Nature, 2012 - nature.com
The discovery of microRNAs (miRNAs) almost two decades ago established a new
paradigm of gene regulation. During the past ten years these tiny non-coding RNAs have …
paradigm of gene regulation. During the past ten years these tiny non-coding RNAs have …
miRNA dosage control in development and human disease
In mammals, miRNAs recognize target mRNAs via base pairing, which leads to a complex
'multiple-to-multiple'regulatory network. Previous studies have focused on the regulatory …
'multiple-to-multiple'regulatory network. Previous studies have focused on the regulatory …
Decoding the role of miRNAs in multiple myeloma pathogenesis: a focus on signaling pathways
Multiple myeloma (MM) is a cancer of plasma cells that has been extensively studied in
recent years, with researchers increasingly focusing on the role of microRNAs (miRNAs) in …
recent years, with researchers increasingly focusing on the role of microRNAs (miRNAs) in …
microRNA therapeutics in cancer—an emerging concept
MicroRNAs (miRNAs) are an evolutionarily conserved class of small, regulatory non-coding
RNAs that negatively regulate protein coding gene and other non-coding transcripts …
RNAs that negatively regulate protein coding gene and other non-coding transcripts …
The dark side of foetal bovine serum in extracellular vesicle studies
Extracellular vesicles (EVs) have been shown to be involved in cell‐cell communication and
to take part in both physiological and pathological processes. Thanks to their exclusive …
to take part in both physiological and pathological processes. Thanks to their exclusive …