Predictive thermodynamic modeling of poorly specified mixtures and applications in conceptual fluid separation process design

T Specht, H Hasse, F Jirasek - Industrial & Engineering Chemistry …, 2023 - ACS Publications
In many chemical engineering processes, mixtures occur whose composition is not well-
known. Simulations of processes with such poorly specified mixtures are basically …

Hybridizing physical and data-driven prediction methods for physicochemical properties

F Jirasek, R Bamler, S Mandt - Chemical Communications, 2020 - pubs.rsc.org
We present a generic way to hybridize physical and data-driven methods for predicting
physicochemical properties. The approach 'distills' the physical method's predictions into a …

Rational method for defining and quantifying pseudo-components based on NMR spectroscopy

T Specht, K Münnemann, H Hasse… - Physical Chemistry …, 2023 - pubs.rsc.org
Poorly specified mixtures, whose composition is unknown, are ubiquitous in chemical and
biochemical engineering. In the present work, we propose a rational method for defining and …

HybridGamma: A thermodynamically consistent framework for hybrid modelling of activity coefficients

U Di Caprio, J Degrève, P Hellinckx, S Waldherr… - Chemical Engineering …, 2023 - Elsevier
Predicting molecular interactions is a crucial step for chemical process modeling. It requires
the full knowledge of the analyzed system, however, this is often impossible in complex real …

Automated methods for identification and quantification of structural groups from nuclear magnetic resonance spectra using support vector classification

T Specht, K Münnemann, H Hasse… - Journal of Chemical …, 2021 - ACS Publications
Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool for elucidating the
structure of unknown components and the composition of liquid mixtures. However, these …

Automated nuclear magnetic resonance fingerprinting of mixtures

T Specht, J Arweiler, J Stüber… - Magnetic …, 2024 - Wiley Online Library
Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool for qualitative and
quantitative analysis. However, for complex mixtures, determining the speciation from NMR …

Application of NEAT for the simulation of liquid–liquid extraction processes with poorly specified feeds

F Jirasek, J Burger, H Hasse - AIChE Journal, 2020 - Wiley Online Library
The conceptual design of fluid separation processes is particularly challenging if the
considered mixtures are poorly specified, since classical thermodynamic models cannot be …

Estimating activity coefficients of target components in poorly specified mixtures with NMR spectroscopy and COSMO-RS

T Specht, K Münnemann, F Jirasek, H Hasse - Fluid Phase Equilibria, 2020 - Elsevier
Poorly specified mixtures are common in process engineering, especially in bioprocess
engineering. The properties of such mixtures of unknown composition cannot be described …

Measurement and modeling of the solubility of α-lactose in water-ethanol electrolyte solutions at 298.15 K

E Baumeister, J Voggenreiter, M Kohns, J Burger - Fluid Phase Equilibria, 2022 - Elsevier
The present work reports experimental data of the solubility of α-lactose in solutions of water-
ethanol-NaCl and water-ethanol-CaCl 2 at 298.15 K. For low ethanol contents, the salts …

Application of NEAT for determining the composition dependence of activity coefficients in poorly specified mixtures

F Jirasek, J Burger, H Hasse - Chemical Engineering Science, 2019 - Elsevier
Poorly specified mixtures, of which the composition is only partially known, are important in
many fields. In a recent work of our group, the method NEAT for estimating activity …