The nucleophilic addition of carbon nucleophiles to amides has traditionally been a difficult
task, both due to reactivity and selectivity problems. When successful, these processes …

Amides are a class of easily available compounds, and widely serve as versatile
intermediates in organic synthesis and medicinal chemistry. Amide-based transformations …

The combination of transition‐metal catalysis and organocatalysis increasingly offers
chemists opportunities to realize diverse unprecedented chemical transformations. By …

The selective transformation of a less reactive carbonyl moiety in the presence of more
reactive ones can realize straightforward and environmentally benign chemical processes …

A unified total synthesis of stemoamide-type alkaloids is reported. Our synthetic approach
features the chemoselective convergent assembly of five-membered building blocks via …

The catalytic asymmetric geminal bis-nucleophilic addition to nonreactive functional groups
is a type of highly desirable yet challenging transformation in organic chemistry. Here, we …

Nucleophilic addition to amides has been recognized as a promising transformation for total
synthesis of complex alkaloids. Amides can accept two different organometallic reagents …

A strategy for the mild generation of synthetically valuable α-amino radicals from robust
tertiary amide building blocks has been developed. By combining Vaska's complex …

An Ir-catalyzed reductive formation of functionalized nitrones from N-hydroxyamides was
reported. The reaction took place through two types of iridium-catalyzed reactions including …

Reported herein is the first direct, metal‐catalyzed reductive functionalization of secondary
amides to give functionalized amines and heterocycles. The method is shown to have …