Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

Cellular senescence is a cell state implicated in various physiological processes and a wide
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …

Background Cellular senescence is a key mechanism that drives age-related diseases, but
has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a …

Cellular senescence has historically been viewed as an irreversible cell-cycle arrest
mechanism that acts to protect against cancer, but recent discoveries have extended its …

For most species, aging promotes a host of degenerative pathologies that are characterized
by debilitating losses of tissue or cellular function. However, especially among vertebrates …

Aging is the largest risk factor for most chronic diseases, which account for the majority of
morbidity and health care expenditures in developed nations. New findings suggest that …

Cellular senescence is an important mechanism for preventing the proliferation of potential
cancer cells. Recently, however, it has become apparent that this process entails more than …

Dysregulated inflammation is a central pathological process in diverse disease states.
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory …

Chronic inflammation is associated with aging and plays a causative role in several age-
related diseases such as cancer, atherosclerosis and osteoarthritis. The source of this …

Simple Summary A fundamental feature of cellular senescence is the emergence of the
Senescence-Associated Secretory Phenotype (SASP), which represents a considerable …