Men and women exhibit differences in the development and progression of Alzheimer's
disease (AD). The factors underlying the sex differences in AD are not well understood. This …

After advanced age, female sex is the major risk factor for late-onset Alzheimer's disease
(AD), the most common cause of dementia affecting over 24 million people worldwide. The …

Estrogens are the primary female sex hormones and play important roles in both
reproductive and non-reproductive systems. Estrogens can be synthesized in non …

Aging is an inevitable biological process characterized by a progressive decline in
physiological function and increased susceptibility to disease. The detrimental effects of …

Along with advanced age and apolipoprotein E (APOE)-4 genotype, female sex is a major
risk factor for develo** late-onset Alzheimer's disease (AD). Considering that AD …

Normal ageing is associated with impairments in cognitive function, including memory.
These impairments are linked, not to a loss of neurons in the forebrain, but to specific and …

Estrogen is a fundamental regulator of the metabolic system of the female brain and body.
Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial …

Perimenopause is a midlife transition state experienced by women that occurs in the context
of a fully functioning neurological system and results in reproductive senescence. Although …

Objective: This observational multimodality brain imaging study investigates emergence of
endophenotypes of late-onset Alzheimer disease (AD) risk during endocrine transition states …

Objective: Our objective was to provide a scholarly review of the published literature on
menopausal hormonal therapy (MHT), make scientifically valid assessments of the available …