Cardiomyocyte death: mechanisms and translational implications
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide.
Although treatments have improved, development of novel therapies for patients with CVD …
Although treatments have improved, development of novel therapies for patients with CVD …
Molecular mechanisms of autophagy in the cardiovascular system
Autophagy is a catabolic recycling pathway triggered by various intra-or extracellular stimuli
that is conserved from yeast to mammals. During autophagy, diverse cytosolic constituents …
that is conserved from yeast to mammals. During autophagy, diverse cytosolic constituents …
[HTML][HTML] Metabolic maturation media improve physiological function of human iPSC-derived cardiomyocytes
DAM Feyen, WL McKeithan, AAN Bruyneel, S Spiering… - Cell reports, 2020 - cell.com
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have enormous potential
for the study of human cardiac disorders. However, their physiological immaturity severely …
for the study of human cardiac disorders. However, their physiological immaturity severely …
[HTML][HTML] Autophagy and oxidative stress in cardiovascular diseases
Autophagy is a highly conserved degradation process by which intracellular components,
including soluble macromolecules (eg nucleic acids, proteins, carbohydrates, and lipids) …
including soluble macromolecules (eg nucleic acids, proteins, carbohydrates, and lipids) …
The ubiquitin-proteasome system and autophagy: Coordinated and independent activities
V Cohen-Kaplan, I Livneh, N Avni… - The international journal …, 2016 - Elsevier
The living cell is an ever changing, responsive, and adaptive environment where proteins
play key roles in all processes and functions. While the scientific community focused for a …
play key roles in all processes and functions. While the scientific community focused for a …
Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy
CC Tan, JT Yu, MS Tan, T Jiang, XC Zhu, L Tan - Neurobiology of aging, 2014 - Elsevier
Neurodegenerative diseases, such as Alzheimer's disease Parkinson's disease,
Huntington's disease, and amyotrophic lateral sclerosis, share a common cellular and …
Huntington's disease, and amyotrophic lateral sclerosis, share a common cellular and …
Akt‐mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth
S Marchi, M Corricelli, A Branchini, VAM Vitto… - The EMBO …, 2019 - embopress.org
Although mitochondria play a multifunctional role in cancer progression and Ca2+ signaling
is remodeled in a wide variety of tumors, the underlying mechanisms that link mitochondrial …
is remodeled in a wide variety of tumors, the underlying mechanisms that link mitochondrial …
Insight into the role of the PI3K/Akt pathway in ischemic injury and post-infarct left ventricular remodeling in normal and diabetic heart
B Walkowski, M Kleibert, M Majka, M Wojciechowska - Cells, 2022 - mdpi.com
Despite the significant decline in mortality, cardiovascular diseases are still the leading
cause of death worldwide. Among them, myocardial infarction (MI) seems to be the most …
cause of death worldwide. Among them, myocardial infarction (MI) seems to be the most …
Nrf2 deficiency exaggerates doxorubicin‐induced cardiotoxicity and cardiac dysfunction
S Li, W Wang, T Niu, H Wang, B Li… - Oxidative medicine …, 2014 - Wiley Online Library
The anticancer therapy of doxorubicin (Dox) has been limited by its acute and chronic
cardiotoxicity. In addition to a causative role of oxidative stress, autophagy appears to play …
cardiotoxicity. In addition to a causative role of oxidative stress, autophagy appears to play …
Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway
C Pennanen, V Parra, C Lopez-Crisosto… - Journal of cell …, 2014 - journals.biologists.com
Cardiomyocyte hypertrophy has been associated with diminished mitochondrial metabolism.
Mitochondria are crucial organelles for the production of ATP, and their morphology and …
Mitochondria are crucial organelles for the production of ATP, and their morphology and …