Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …

Abstract Notch (Notch1 through 4) are transmembrane receptors that play a fundamental
role in cell differentiation and function. Notch receptors are activated following interactions …

Approximately 1.1 billion people currently live in countries where consanguineous
marriages are customary, and among them one in every three marriages is between …

Human limbs emerge during the fourth post-conception week as mesenchymal buds, which
develop into fully formed limbs over the subsequent months. This process is orchestrated by …

Notch is a cell–cell signaling pathway that is involved in a host of activities including
development, oncogenesis, skeletal homeostasis, and much more. More specifically, recent …

Indian Hedgehog (Ihh) regulates chondrocyte and osteoblast differentiation through the
Glioma-associated oncogene homolog (Gli) transcription factors. Previous in vitro studies …

Isolated growth disorders are often monogenic. Specific genetic causes typically have
specific biochemical and/or phenotype characteristics which are diagnostically helpful …

We delineated a syndromic recessive preaxial brachydactyly with partial duplication of
proximal phalanges to 16.8 Mb over 4 chromosomes. High-throughput sequencing of all 177 …

Objective Next generation sequencing (NGS) has expanded the diagnostic paradigm
turning the focus to the growth plate. The aim of the study was to determine the prevalence …

The evolutionary history for dwarfism in chickens remains an enigma. Herein, we explore the
evolution of the Serama, the smallest breed of chicken. Leveraging comparative population …