Transcriptional control of microglia phenotypes in health and disease
Microglia are the main resident macrophage population of the CNS and perform numerous
functions required for CNS development, homeostasis, immunity, and repair. Many lines of …
functions required for CNS development, homeostasis, immunity, and repair. Many lines of …
Cellular and molecular characterization of microglia: a unique immune cell population
Microglia are essential for the development and function of the adult brain. Microglia arise
from erythro-myeloid precursors in the yolk sac and populate the brain rudiment early during …
from erythro-myeloid precursors in the yolk sac and populate the brain rudiment early during …
Whole-organism clone tracing using single-cell sequencing
Embryonic development is a crucial period in the life of a multicellular organism, during
which limited sets of embryonic progenitors produce all cells in the adult body. Determining …
which limited sets of embryonic progenitors produce all cells in the adult body. Determining …
Colony-stimulating factor 1 receptor (CSF1R) regulates microglia density and distribution, but not microglia differentiation in vivo
N Oosterhof, LE Kuil, HC van der Linde, SM Burm… - Cell reports, 2018 - cell.com
Microglia are brain-resident macrophages with trophic and phagocytic functions. Dominant
loss-of-function mutations in a key microglia regulator, colony-stimulating factor 1 receptor …
loss-of-function mutations in a key microglia regulator, colony-stimulating factor 1 receptor …
Two phenotypically and functionally distinct microglial populations in adult zebrafish
S Wu, LTM Nguyen, H Pan, S Hassan, Y Dai, J Xu… - Science …, 2020 - science.org
Microglia are the tissue-resident macrophages in the central nervous system and are
critically involved in immune defense, neural development and function, and …
critically involved in immune defense, neural development and function, and …
In situ and transcriptomic identification of microglia in synapse-rich regions of the develo** zebrafish brain
Microglia are brain resident macrophages that play vital roles in central nervous system
(CNS) development, homeostasis, and pathology. Microglia both remodel synapses and …
(CNS) development, homeostasis, and pathology. Microglia both remodel synapses and …
[HTML][HTML] Dynamic changes in microglial and macrophage characteristics during degeneration and regeneration of the zebrafish retina
Background In contrast to mammals, zebrafish have the capacity to regenerate retinal
neurons following a variety of injuries. Two types of glial cells, Müller glia (MG) and …
neurons following a variety of injuries. Two types of glial cells, Müller glia (MG) and …
Dominant-acting CSF1R variants cause microglial depletion and altered astrocytic phenotype in zebrafish and adult-onset leukodystrophy
WM Berdowski, HC van der Linde, M Breur… - Acta …, 2022 - Springer
Tissue-resident macrophages of the brain, including microglia, are implicated in the
pathogenesis of various CNS disorders and are possible therapeutic targets by their …
pathogenesis of various CNS disorders and are possible therapeutic targets by their …
RNAseq Profiling of Leukocyte Populations in Zebrafish Larvae Reveals a cxcl11 Chemokine Gene as a Marker of Macrophage Polarization During Mycobacterial …
Macrophages are phagocytic cells from the innate immune system, which forms the first line
of host defense against invading pathogens. These highly dynamic immune cells can adopt …
of host defense against invading pathogens. These highly dynamic immune cells can adopt …
Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications
Y **, Y Song, J Lin, T Liu, G Li, B Lai, Y Gu… - Burns & …, 2023 - academic.oup.com
Spinal cord injury (SCI) is an incurable trauma that frequently results in partial or complete
loss of motor and sensory function. Massive neurons are damaged after the initial …
loss of motor and sensory function. Massive neurons are damaged after the initial …