The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

African Americans have higher incidence of, and mortality from, many health-related
problems than European Americans. They also have a 15 to 20-fold higher prevalence of …

We conduct high coverage (> 30×) whole-genome sequencing of 180 individuals from 12
indigenous African populations. We identify millions of unreported variants, many predicted …

Fields as diverse as human genetics and sociology are increasingly using polygenic scores
based on genome-wide association studies (GWAS) for phenotypic prediction. However …

In the light of substantial discoveries in epithelial and hair pigmentation pathophysiology,
this review summarizes the current understanding of skin pigmentation mechanisms …

Modern humans inhabit a variety of environments and are exposed to a plethora of selective
pressures, leading to multiple genetic adaptations to local environmental conditions. These …

Abstract We initiate the Westlake BioBank for Chinese (WBBC) pilot project with 4,535 whole-
genome sequencing (WGS) individuals and 5,841 high-density genoty** individuals, and …

Human skin and hair color are visible traits that can vary dramatically within and across
ethnic populations. The genetic makeup of these traits—including polymorphisms in the …

Melanins, the main pigments of the skin and hair in mammals, are synthesized within
membrane-bound organelles of melanocytes called melanosomes. Melanosome structure …

The primary biological role of human skin pigmentation is as a mediator of penetration of
ultraviolet radiation (UVR) into the deep layers of skin and the cutaneous circulation. Since …