The wide implementation of next-generation sequencing (NGS) technologies has
revolutionized the field of medical genetics. However, the short read lengths of currently …

Climate change with altered pest-disease dynamics and rising abiotic stresses threatens
resource-constrained agricultural production systems worldwide. Genomics-assisted …

In this report, we describe a simple correction for multiple testing of single-nucleotide
polymorphisms (SNPs) in linkage disequilibrium (LD) with each other, on the basis of the …

DNA pooling is a practical way to reduce the cost of large-scale association studies to
identify susceptibility loci for common diseases. Pooling allows allele frequencies in groups …

There have been increasing efforts to relate drug efficacy and disease predisposition with
genetic polymorphisms. We present statistical tests for association of haplotype frequencies …

Haplotypes have gained increasing attention in the map** of complex-disease genes,
because of the abundance of single-nucleotide polymorphisms (SNPs) and the limited …

We investigated the effect of multiple susceptibility alleles at a single disease locus on the
statistical power of a likelihood ratio test to detect association between alleles at a marker …

In the study of complex traits, the utility of linkage analysis and single marker association
tests can be limited for researchers attempting to elucidate the complex interplay between a …

Abstract Catechol-O-methyltransferase (COMT) has been shown to be critical for prefrontal
dopamine flux, prefrontal cortex-dependent cognition and activation. Several potentially …

This well-organized and clearly written text has a unique focus on methods of identifying the
joint effects of genes and environment on disease patterns. It follows the natural sequence of …