In 1999, the World Health Organization (WHO) estimated that one-third of the world's
population had latent tuberculosis infection (LTBI), which was recently updated to one …

Investigation of contacts of patients with tuberculosis (TB) is a priority for TB control in high-
income countries, and is increasingly being considered in resource-limited settings. This …

In 2005, CDC published guidelines for using the QuantiFERON-TB Gold test (QFT-
G)(Cellestis Limited, Carnegie, Victoria, Australia)(CDC. Guidelines for using the …

A granuloma is defined as an inflammatory mononuclear cell infiltrate that, while capable of
limiting growth of Mycobacterium tuberculosis, also provides a survival niche from which the …

Background: Interferon-γ–release assays (IGRAs) are alternatives to the tuberculin skin test
(TST). A recent meta-analysis showed that IGRAs have high specificity, even among …

Background We aimed to assess whether interferon-γ release assays (IGRAs) can predict
the development of active tuberculosis and whether the predictive ability of these tests is …

We conducted a systematic review and meta-analysis to compare the accuracy of the
QuantiFERON-TB® Gold In-Tube (QFT-G-IT) and the T-SPOT®. TB assays with the …

Currently there are no sufficiently validated biomarkers to aid the evaluation of new
tuberculosis vaccine candidates, the improvement of tuberculosis diagnostics or the …

Tuberculosis control relies on the identification and preventive treatment of individuals who
are latently infected with Mycobacterium tuberculosis. However, direct identification of latent …

Human infection with Mycobacterium tuberculosis can progress to active disease, be
contained as latent infection, or be eradicated by the host response. Tuberculosis …