Fibroblast-like synoviocytes (FLS) are mesenchymal-derived cells that play an important role
in the physiology of the synovium by producing certain components of the synovial fluid and …

Metabolomic studies of body fluids show that immune‐mediated inflammatory diseases such
as rheumatoid arthritis (RA) are associated with metabolic disruption. This is likely to reflect …

An increasing number of studies show how changes in intracellular metabolic pathways
alter tumor and immune cell function. However, little information about metabolic changes in …

New strategies to rapidly develop broad-spectrum antiviral therapies are urgently required
for emerging and re-emerging viruses. Host-targeting antivirals (HTAs) that target the …

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable
reference for gastroenterologists, hepatologists, family physicians, internists, pathologists …

Systemic treatments for rheumatoid arthritis are associated with many side effects. This study
aimed to minimize the side effects associated with the systemic administration of leflunomide …

Neutrophils, as essential component of the innate immune response, form a crucial part in
the defence mechanisms through the release of extracellular traps (NETs). These web-like …

Objectives. Biologic drugs have revolutionized the care of RA, but are expensive and not
universally effective. To further understand the inflammatory mechanisms underlying RA and …

Glucose metabolism is considerably increased in inflamed joints of rheumatoid arthritis (RA)
patients at early stages. Fibroblast-like synoviocytes (FLSs) activation and subsequent joint …

Expression and activity of several key drug metabolizing enzymes (DMEs) and transporters
are altered in various pathophysiological conditions, leading to altered drug metabolism and …