Platinum‐induced peripheral neurotoxicity (PIPN) is a common side effect of platinum‐
based chemotherapy that may cause dose reduction and discontinuation, with oxaliplatin …

Current management of locally advanced rectal cancer achieves high cure rates, distant
metastatic spread being the main cause of patients' death. Total neoadjuvant therapy (TNT) …

Deep learning (DL) can accelerate the prediction of prognostic biomarkers from routine
pathology slides in colorectal cancer (CRC). However, current approaches rely on …

Background A prospective, pooled analysis of six randomised phase 3 trials was done to
investigate disease-free survival regarding non-inferiority of 3 months versus 6 months of …

Background Improved markers of prognosis are needed to stratify patients with early-stage
colorectal cancer to refine selection of adjuvant therapy. The aim of the present study was to …

Background Systemic relapses remain a major problem in locally advanced rectal cancer.
Using short-course radiotherapy followed by chemotherapy and delayed surgery, the Rectal …

The problems with anticancer therapy are resistance and toxicity. From 3000 Cisplatin
derivatives tested as antitumor agents, most of them have been rejected, due to toxicity. The …

Colorectal cancer (CRC) is a heterogenous malignancy underpinned by dysregulation of
cellular signaling pathways. Previous literature has implicated aberrant JAK/STAT3 signal …

Background: Oxaliplatin, combined with capecitabine (CAPOX) or infused 5-fluorouracil
(FOLFOX), is standard of care in the adjuvant treatment of colorectal cancer (CRC) …

We set out to determine the usability of serum neurofilament light chain (sNfL), serum glial
fibrillary acidic protein (sGFAP), and retinal parameters by using optical coherence …