The complement system has been considered for a long time as a simple lytic cascade,
aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it …

The complement system is important for cellular integrity and tissue homeostasis.
Complement activation mediates the removal of microorganisms and the clearance of …

Background Visual impairment in elderly people is a considerable health problem that
significantly affects quality of life of millions worldwide. The magnitude of this issue is …

Although genome-wide association (GWA) studies for common variants have thus far
succeeded in explaining only a modest fraction of the genetic components of human …

Age-related macular degeneration (AMD) is a common cause of blindness in older
individuals. To accelerate the understanding of AMD biology and help design new …

Age-related macular degeneration (AMD) is the leading cause of legal blindness in the
industrialized world. AMD is characterized by accumulation of extracellular deposits, namely …

Background Age-related macular degeneration is the most common cause of blindness in
Western populations. Susceptibility is influenced by age and by genetic and environmental …

During the past ten years, dramatic advances have been made in unraveling the biological
bases of age-related macular degeneration (AMD), the most common cause of irreversible …

A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …

We carried out a genome-wide association study of IgA nephropathy, a major cause of
kidney failure worldwide. We studied 1,194 cases and 902 controls of Chinese Han …