Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société …
Background Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …
Rationalizing antimicrobial therapy in the ICU: a narrative review
The massive consumption of antibiotics in the ICU is responsible for substantial ecological
side effects that promote the dissemination of multidrug-resistant bacteria (MDRB) in this …
side effects that promote the dissemination of multidrug-resistant bacteria (MDRB) in this …
Beta-lactam antibiotic therapeutic drug monitoring in critically ill patients: a systematic review and meta-analysis
R Pai Mangalore, A Ashok, SJ Lee… - Clinical Infectious …, 2022 - academic.oup.com
Therapeutic drug monitoring (TDM) of beta-lactam antibiotics is recommended to address
the variability in exposure observed in critical illness. However, the impact of TDM-guided …
the variability in exposure observed in critical illness. However, the impact of TDM-guided …
Microbiota–gut–brain axis and epilepsy: a review on mechanisms and potential therapeutics
M Ding, Y Lang, H Shu, J Shao, L Cui - Frontiers in Immunology, 2021 - frontiersin.org
The gut–brain axis refers to the bidirectional communication between the gut and brain, and
regulates intestinal homeostasis and the central nervous system via neural networks and …
regulates intestinal homeostasis and the central nervous system via neural networks and …
Clinical pharmacokinetics in kidney disease: fundamental principles
Kidney disease is an increasingly common comorbidity that alters the pharmacokinetics of
many drugs. Prescribing to patients with kidney disease requires knowledge about the drug …
many drugs. Prescribing to patients with kidney disease requires knowledge about the drug …
[HTML][HTML] Model-informed precision dosing: State of the art and future perspectives
Abstract Model-informed precision dosing (MIPD) stands as a significant development in
personalized medicine to tailor drug dosing to individual patient characteristics. MIPD moves …
personalized medicine to tailor drug dosing to individual patient characteristics. MIPD moves …
Failure of target attainment of beta-lactam antibiotics in critically ill patients and associated risk factors: a two-center prospective study (EXPAT)
Background Early and appropriate antibiotic dosing is associated with improved clinical
outcomes in critically ill patients, yet target attainment remains a challenge. Traditional …
outcomes in critically ill patients, yet target attainment remains a challenge. Traditional …
What antibiotic exposures are required to suppress the emergence of resistance for gram-negative bacteria? A systematic review
Background The rates of antibiotic resistance in Gram-negative bacteria are increasing. One
method to minimize resistance emergence may be optimization of antibiotic dosing …
method to minimize resistance emergence may be optimization of antibiotic dosing …
Expert clinical pharmacological advice may make an antimicrobial TDM program for emerging candidates more clinically useful in tailoring therapy of critically ill …
Background Therapeutic drug monitoring (TDM) may represent an invaluable tool for
optimizing antimicrobial therapy in septic patients, but extensive use is burdened by barriers …
optimizing antimicrobial therapy in septic patients, but extensive use is burdened by barriers …
Setting the beta-lactam therapeutic range for critically ill patients: is there a floor or even a ceiling?
OBJECTIVES: Beta-lactam antibiotics exhibit high interindividual variability in drug
concentrations in patients with critical illness which led to an interest in the use of …
concentrations in patients with critical illness which led to an interest in the use of …