Astrocytes are abundant glial cells in the central nervous system (CNS) that play active roles
in health and disease. Recent technologies have uncovered the functional heterogeneity of …

Despite therapeutic suppression of relapses, multiple sclerosis (MS) patients often
experience subtle deterioration, which extends beyond the definition of “progression …

Aging affects all cell types in the CNS and plays an important role in CNS diseases.
However, the underlying molecular mechanisms driving these age-associated changes and …

Chemokines and their corresponding receptors play crucial roles in orchestrating
inflammatory and immune responses, particularly in the context of pathological conditions …

Abstract In Multiple Sclerosis (MS), inflammatory demyelinated lesions in the brain and
spinal cord lead to neurodegeneration and progressive disability. Remyelination can restore …

With a rapidly aging global population and improvement of outcomes with newer multiple
sclerosis (MS)-specific disease-modifying therapies (DMTs), the epidemiology of MS has …

The interaction between ageing and multiple sclerosis is complex and carries significant
implications for patient care. Managing multiple sclerosis effectively requires an …

Objective Older people with multiple sclerosis (MS) have a less active radiological and
clinical presentation, but many still attain significant levels of disability; but what drives …

In recent years, microRNAs (miRNAs) have gained increased attention from researchers
around the globe. Although it is twenty nucleotides long, it can modulate several gene …

Background and Objectives Clinical onset of multiple sclerosis (MS) after the age of 50 years
is uncommon and associated with a less favorable natural history. The differences in long …